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Enzymes
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L-NIL hydrochloride
L-NIL hydrochloride is a selective inhibitor of inducible nitric oxide synthase (IC50 = 3.3 μM). Learn MoreStarting at: $90.00
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EIT hydrobromide
EIT hydrobromide is a potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively). Learn MoreStarting at: $50.00
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(S)-(+)-Ibuprofen
(S)-(+)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and cyclooxygenase 2 (IC50 values are 12 and 80 μM respectively). Learn MoreStarting at: $55.00
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SC 236
CHPG is a selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Learn MoreStarting at: $110.00
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A 350619 hydrochloride
A 350619 hydrochloride is activates basal sGC and synergistically activates sGC in the presence of NO. Learn MoreStarting at: $129.00
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URB 597
URB 597, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, displays antiallodynic and antihyperalgesic activity in an inflammatory pain model. Learn MoreStarting at: $98.00
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8-CPT-2Me-cAMP, sodium salt
8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Learn MoreStarting at: $125.00
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HLI 373
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3), which blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Learn MoreStarting at: $109.00
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Sirtinol
Sirtinol is a cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Learn MoreStarting at: $125.00
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ITX 3
ITX 3 is a selective inhibitor of TrioN RhoGEF activity, which inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro. Learn MoreStarting at: $109.00
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BPIPP
BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor, which downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). It also inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo. Learn MoreStarting at: $145.00
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PRT 4165
PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1), and inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). Learn MoreStarting at: $65.00
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PD 334581
PD 334581, an analog of PD 184352, is an inhibitor of MEK1. Learn MoreStarting at: $198.00
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Acyclovir
Acyclovir, an antiviral agent, is active against herpes simplex viruses HSV-1 and HSV-2 with EC50 values of 0.85 and 0.86 μM respectively. Learn MoreStarting at: $59.00
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GSK 264220A
GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor with IC50 values of 0.13 and 0.10 μM respectively. Learn MoreStarting at: $119.00
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PF 750
PF 750 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor that displays no activity at a range of other serine hydrolases. Learn MoreStarting at: $149.00
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SID 26681509
SID 26681509 is a potent and reversible human cathepsin L inhibitor with an IC50 value of 56 nM. Learn MoreStarting at: $149.00
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DuP 697
DuP 697 is a potent and selective inhibitor of cyclooxygenase-2 with IC50 values of10 and 800 nM for COX-2 and COX-1 respectively. Learn MoreStarting at: $115.00
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PF 915275
PF 915275 is a potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor that inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. Learn MoreStarting at: $115.00
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RHC 80267
RHC 80267 is an inhibitor of diacylglycerol lipase that potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity. Learn MoreStarting at: $99.00
