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Enzymes
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10Z-Hymenialdisine
10Z-Hymenialdisine is a pan kinase inhibitor that inhibits NF-κB activation and blocks IL-8 production in U937 cells with IC50 values of 1-2 and 0.34-0.48 μM respectively. Learn MoreStarting at: $259.00
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SA 47
SA 47 is a selective inhibitor of fatty acid amide hydrolase (FAAH) that exhibits greater selectivity for FAAH than URB 597 against multiple carboxylesterases. Learn MoreStarting at: $109.00
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OR-486
OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase. Learn MoreStarting at: $90.00
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ML 141
ML 141 is an allosteric inhibitor of Cdc42 GTPase with selectivity for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Learn MoreStarting at: $139.00
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NSC 66811
NSC 66811 is a potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Learn MoreStarting at: $119.00
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L 006235
L 006235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Learn MoreStarting at: $159.00
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CFM 1571 hydrochloride
CFM 1571 hydrochloride is a soluble guanylyl cyclase (sGC) activator (EC50 = 5.49 μM), which inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM). Learn MoreStarting at: $149.00
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BAY 41-2272
BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC)which acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit and inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Learn MoreStarting at: $139.00
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8-pCPT-2-O-Me-cAMP-AM
8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog which induces Rap activation and junction tightening in HUVECs. Learn MoreStarting at: $150.00
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Golgicide A
Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Learn MoreStarting at: $125.00
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N1,N12-Diethylspermine tetrahydrochloride
N1,N12-Diethylspermine tetrahydrochloride is a powerful antineoplastic agent in cultured cells and animal tumors (IC50 = 0.2 μM in L1210 cells). Learn MoreStarting at: $90.00
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Dynole 34-2
Dynole 34-2 is a dynamin I inhibitor (IC50 = 1.3 μM) and inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM). Learn MoreStarting at: $135.00
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OctMAB
OctMAB is a dynamin inhibitor (IC50 = 1.9 μM for dynamin I) which inhibits receptor-mediated endocytosis (IC50 = 16 μM). Learn MoreStarting at: $50.00
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MitMAB
MitMAB is a dynamin inhibitor, which inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Learn MoreStarting at: $50.00
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Salermide
Salermide is a SIRT1 and SIRT2 inhibitor, which exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Learn MoreStarting at: $75.00
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U0126
U0126 is a Potent and selective non-competitive inhibitor of MAP kinase kinase, which inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Learn MoreStarting at: $135.00
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U0124
U0124 is the inactive analog of U0126 which be used as a negative control. Learn MoreStarting at: $99.00
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Thiolutin
Thiolutin is Antibiotic, inhibits bacterial RNA polymerase, Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and suppresses tumor cell-induced angiogenesis. Learn MoreStarting at: $99.00
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AS 1949490
AS 1949490 is a selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC50 values are 0.34 μM and 0.62 μM for mouse and human respectively). Learn MoreStarting at: $100.00
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Pristimerin
Pristimerin is a potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM), which displays antitumor, anti-inflammatory and antimicrobial activities. Learn MoreStarting at: $135.00
