Enzymes

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  • BYK 204165

    BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). Learn More

    Starting at: $95.00

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  • NKH 477

    NKH 477 is a water-soluble analog of forskolin that is a potent activator of adenylyl cyclase which shows some selectivity for cardiac (type V) adenylyl cyclase. Learn More

    Starting at: $150.00

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  • YM 750

    YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM) which exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo. Learn More

    Starting at: $95.00

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  • Banoxantrone dihydrochloride

    Banoxantrone dihydrochloride is a bioreductive prodrug which activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Learn More

    Starting at: $125.00

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  • MDL 12330A hydrochloride

    MDL 12330A hydrochloride is an inhibitor of adenylyl cyclase, which also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells. Learn More

    Starting at: $85.00

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  • 4-HQN

    4-HQN is an inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM), which displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent mitochondrial and cell damage in rat heart. Learn More

    Starting at: $69.00

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  • S 32826

    S 32826 is an inhibitor of autotaxin (IC50 = 9 nM), which displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ)and inhibits LPA release from adipocytes (IC50 = 90 nM). Learn More

    Starting at: $135.00

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  • BYK 49187

    Chromanol 293B is a blocker of the slow delayed rectifier K+ current (IKs) (IC50 = 1-10 μM), which blocks the CFTR chloride current (ICFTR) (IC50 = 19 μM). Learn More

    Starting at: $70.00

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  • HA 130

    HA 130 is a selective autotaxin inhibitor (IC50 = 28 nM), which binds and inhibits autotaxin reversibly. Learn More

    Starting at: $135.00

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  • Methylmalonate

    Imethylmalonate intracellularly produces malonate and induces apoptotic cell death in striatal neurons. Learn More

    Starting at: $70.00

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  • Topotecan hydrochloride

    Topotecan hydrochloride is a DNA topoisomerase I inhibitor which induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Learn More

    Starting at: $45.00

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  • EB 47

    EB 47 is a potent inhibitor of PARP-1 (IC50 = 45 nM), which reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model. Learn More

    Starting at: $145.00

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  • EBPC

    EBPC is a potent aldose reductase inhibitor, which improves the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells through an increase in ERK activity. Learn More

    Starting at: $89.00

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  • CI 976

    CI 976 is a selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM), which inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM). Learn More

    Starting at: $95.00

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  • L189

    L189 is a DNA ligase I, III and IV inhibitor with IC50 values of 5, 9 and 5 μM respectively. Learn More

    Starting at: $119.00

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  • 1,9-Dideoxyforskolin

    1,9-Dideoxyforskolin is an inactive analog of forskolin. Learn More

    Starting at: $58.00

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  • KH 7

    KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo), which inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM, and locks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM. Learn More

    Starting at: $109.00

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  • TC HSD 21

    TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 values are 6 and 40 nM at human and mouse 17β-HSD3 respectively). Learn More

    Starting at: $109.00

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  • Ceranib 1

    Ceranib 1 is a ceramidase inhibitor which inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM), and induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells. Learn More

    Starting at: $85.00

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  • Bromosporine

    Bromosporine is a broad spectrum bromodomain inhibitor, which accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM. Learn More

    Starting at: $199.00

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