GTPase

MitMAB

MitMAB is a dynamin inhibitor, which inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Learn More

Starting at: $50.00

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OctMAB

OctMAB is a dynamin inhibitor (IC50 = 1.9 μM for dynamin I) which inhibits receptor-mediated endocytosis (IC50 = 16 μM). Learn More

Starting at: $50.00

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Dynole 34-2

Dynole 34-2 is a dynamin I inhibitor (IC50 = 1.3 μM) and inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM). Learn More

Starting at: $135.00

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Golgicide A

Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Learn More

Starting at: $125.00

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8-pCPT-2-O-Me-cAMP-AM

8-pCPT-2-O-Me-cAMP-AM is a selective Epac activator; cAMP analog which induces Rap activation and junction tightening in HUVECs. Learn More

Starting at: $150.00

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ITX 3

ITX 3 is a selective inhibitor of TrioN RhoGEF activity, which inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro. Learn More

Starting at: $109.00

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8-CPT-2Me-cAMP, sodium salt

8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Learn More

Starting at: $125.00

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ML 141

ML 141 is an allosteric inhibitor of Cdc42 GTPase with selectivity for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Learn More

Starting at: $139.00

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