Other Nuclear Receptors
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GSK 4112
GSK 4112 is a selective Rev-Erbα agonist (EC50 = 250 nM) which enhances recruitment of nuclear receptor co-repressor (NCoR) peptide to Rev-Erbα; causes acute suppression of Bmal1 gene transcription. Learn MoreStarting at: $100.00
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SR 8278
SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM) and blocks activity of Rev-Erbα agonist GSK 4112 in HEK293 cells. Learn MoreStarting at: $115.00
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AC 45594
AC 45594 is a selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM), which inhibits SFRE-mediated transcription. Learn MoreStarting at: $70.00
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DLPC
DLPC is a selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro, which induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose, and exhibits antidiabetic effects. Learn MoreStarting at: $50.00
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GC 1
GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively), which displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Learn MoreStarting at: $115.00
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Z-Guggulsterone
Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Learn MoreStarting at: $139.00
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SID 7969543
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor that inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro with an IC50 value of 30 nM). Learn MoreStarting at: $89.00
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Guggulsterone
Guggulsterone is a broad spectrum steroid receptor ligand that binds with high affinity to mineralocorticoid receptors and lower affinity to progesterone, androgen and glucocorticoid receptors. Learn MoreStarting at: $109.00