EGFR

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  • AG 18

    AG 18 is an inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 μM respectively, whichi inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling. Learn More

    Starting at: $80.00

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  • HDS 029

    HDS 029 is a potent inhibitor of the ErbB receptor family that inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells. Learn More

    Starting at: $85.00

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  • HKI 357

    HKI 357 is a potent, irreversible inhibitor of ErbB2 (HER2) and EGFR that suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Learn More

    Starting at: $189.00

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  • BIBU 1361 dihydrochloride

    BIBU 1361 dihydrochloride is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that inhibits growth of established human xenografts in athymic mice. Learn More

    Starting at: $85.00

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  • Methyl 2,5-dihydroxycinnamate

    Methyl 2,5-dihydroxycinnamate is an inhibitor of EGF receptor-associated tyrosine kinases. Learn More

    Starting at: $81.00

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  • GW 583340 dihydrochloride

    GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively), which selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Learn More

    Starting at: $139.00

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  • PD 158780

    PD 158780 is a potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively), which induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells. Learn More

    Starting at: $135.00

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  • AG 825

    AG 825 is a selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Learn More

    Starting at: $90.00

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  • AG 556

    Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 1.1 μM) and selective over ErbB2 (IC50 > 500 μM). Learn More

    Starting at: $80.00

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  • Tyrphostin B44, (+) enantiomer

    Tyrphostin B44, (+) enantiomer is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.86 μM). Learn More

    Starting at: $105.00

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  • AG 494

    AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Learn More

    Starting at: $85.00

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  • AG 555

    AG 555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Learn More

    Starting at: $80.00

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  • Tyrphostin B44, (-) enantiomer

    Tyrphostin B44, (-) enantiomer is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.4 μM), which is more active than the (+) enantiomer. Selective over ErbB2. Learn More

    Starting at: $75.00

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  • AG 490

    AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Learn More

    Starting at: $50.00

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  • Lavendustin A

    Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM), which inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM). Learn More

    Starting at: $115.00

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  • AG 99

    AG 99 is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Learn More

    Starting at: $85.00

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  • JNJ 28871063 hydrochloride

    JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor with IC50 values of 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively. Learn More

    Starting at: $139.00

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17 Item(s)

per page