Cytokine and NF-κB Signaling
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AS 101
AS 101 is a immunomodulator which inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release. Learn MoreStarting at: $80.00
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Bropirimine
Bropirimine, an Immunomodulatory and antitumor compound, induces interferon (IFN)-α/β production and augments natural killer (NK) cell activity. Orally active. Learn MoreStarting at: $93.00
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Pirfenidone
Pirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis that regulates cytokine levels following oral administration in vivo. Learn MoreStarting at: $89.00
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BTZO 1
BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM), which activates antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Learn MoreStarting at: $95.00
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4-IPP
4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF), which acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Learn MoreStarting at: $105.00
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(D)-(+)-Neopterin
(D)-(+)-Neopterin is a precursor of biopterin synthesis. Learn MoreStarting at: $45.00
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(±)-CPSI 1306
(±)-CPSI 1306 is reported to be a macrophage inhibitory factor (MIF) inhibitor. Learn MoreStarting at: $145.00
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Pyrrolidinedithiocarbamate ammonium
This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP. Learn MoreStarting at: $65.00
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ML 130
ML 130 is a potent and selective inhibitor of NOD1 that inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Learn MoreStarting at: $119.00
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CID 2858522
CID 2858522 selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway and inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Learn MoreStarting at: $109.00
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Ro 106-9920
Ro 106-9920 is a small molecule inhibitor of NF-κB-dependent expression of TNF-α, interleukin-1β, and interleukin-6. Learn MoreStarting at: $109.00
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Cardamonin
Cardamonin is a chalone analog that display anti-inflammatory activity. Learn MoreStarting at: $110.00
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Withaferin A
Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. It prevents NF-κB activation by inhibiting activation of IKKβ. Learn MoreStarting at: $90.00
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SD 1008
SD 1008 is a JAK2/STAT3 signaling pathway inhibitor, which inhibits activation of STAT3, JAK2 and Src. Learn MoreStarting at: $109.00
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SR 11302
SB 205384 is a GABAA receptor modulator; slows current decay. Learn MoreStarting at: $110.00