Signal Transduction

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  • BTZO 1

    BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM), which activates antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Learn More

    Starting at: $95.00

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  • W-5 hydrochloride

    W-5 hydrochloride is a Calmodulin antagonist that inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM. Learn More

    Starting at: $99.00

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  • Cardionogen 1

    Cardionogen 1, a wnt signaling modulator, potently inhibits Wnt/β-catenin-dependent transcription in murine ES cells and zebrafish embryos and Enlarges heart size via cardiomyocyte hyperplasia; induces ES cell cardiac differentiation. Learn More

    Starting at: $139.00

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  • SNOG

    SNOG is a carrier of NO, relaxing smooth muscle and inhibiting platelet aggregation. Learn More

    Starting at: $59.00

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  • Calmidazolium chloride

    Calmidazolium chloride is a calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Learn More

    Starting at: $99.00

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  • Pirfenidone

    Pirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis that regulates cytokine levels following oral administration in vivo. Learn More

    Starting at: $89.00

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  • STO-609 acetate

    STO-609 acetate is a selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase. The Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively. Learn More

    Starting at: $69.00

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  • Dibutyryl-cAMP, sodium salt

    LY 333531 hydrochloride is an isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). Learn More

    Starting at: $55.00

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  • SIN-1 chloride

    ZK 200775 is a competitive AMPA/kainate antagonist. Learn More

    Starting at: $98.00

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  • Bropirimine

    Bropirimine, an Immunomodulatory and antitumor compound, induces interferon (IFN)-α/β production and augments natural killer (NK) cell activity. Orally active. Learn More

    Starting at: $93.00

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  • 4-IPP

    4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF), which acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Learn More

    Starting at: $105.00

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  • W-7 hydrochloride

    W-7 hydrochloride is a calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase. Learn More

    Starting at: $99.00

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  • iCRT 14

    iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) with IC50 of 40.3 nM in assays of Wnt pathway activity. Learn More

    Starting at: $139.00

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  • BI 6015

    BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma. Learn More

    Starting at: $129.00

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  • W-13 hydrochloride

    W-13 hydrochloride is a calmodulin antagonist that inhibits calmodulin activated PDE activity with an IC50 of 68 μM. Learn More

    Starting at: $99.00

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  • A-7 hydrochloride

    A-7 hydrochloride is a potent calmodulin antagonist that inhibits calmodulin-activated PDE activity with an IC50 of 3 μM. Learn More

    Starting at: $89.00

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  • SNAP

    SNAP is a stable analog of endogenous S-nitroso compounds. Learn More

    Starting at: $59.00

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  • 8-Bromo-cAMP (sodium salt)

    8-Bromo-cAMP(sodium salt) is a cell-permeable cAMP analog and activator of protein kinase A. Learn More

    Starting at: $59.00

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  • CID 5951923

    CID 5951923 is an inhibitor of Krüppel-like factor 5 (KLF5) transcription factor. Learn More

    Starting at: $149.00

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  • L-Arginine

    L-Arginine is a precursor in the formation of nitric oxide. Learn More

    Starting at: $49.00

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