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Signal Transduction
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exo-IWR 1
exo-IWR 1 is negative control for endo-IWR 1. It also exhibits decreased activity against the Wnt/β-catenin pathway. Learn MoreStarting at: $90.00
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PNU 74654
PNU 74654 Binds to β-catenin (KD = 450 nM) and inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway. Learn MoreStarting at: $90.00
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CCT 031374 hydrobromide
CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription, which blocks BIO-induced β-catenin stabilization; reduces nuclear and cytosolic β-catenin levels in mouse L-cells, and inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells. Learn MoreStarting at: $105.00
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(±)-CPSI 1306
(±)-CPSI 1306 is reported to be a macrophage inhibitory factor (MIF) inhibitor. Learn MoreStarting at: $145.00
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Spermine NONOate
Spermine NONOate is a stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC50 = 6.2 μM for relaxation of rabbit aorta, and t½ =39 min at 37°C, pH 7.4, aqueous solution). Learn MoreStarting at: $65.00
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N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide is a pro-drug of the potent vasorelaxant nitroxyl, H-N=O, which it slowly releases in neutral solution. Learn MoreStarting at: $95.00
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(D)-(+)-Neopterin
(D)-(+)-Neopterin is a precursor of biopterin synthesis. Learn MoreStarting at: $45.00
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Bropirimine
Bropirimine, an Immunomodulatory and antitumor compound, induces interferon (IFN)-α/β production and augments natural killer (NK) cell activity. Orally active. Learn MoreStarting at: $93.00
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Pirfenidone
Pirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis that regulates cytokine levels following oral administration in vivo. Learn MoreStarting at: $89.00
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STO-609 acetate
STO-609 acetate is a selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase. The Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively. Learn MoreStarting at: $69.00
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Dibutyryl-cAMP, sodium salt
LY 333531 hydrochloride is an isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). Learn MoreStarting at: $55.00
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SIN-1 chloride
ZK 200775 is a competitive AMPA/kainate antagonist. Learn MoreStarting at: $98.00
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4-IPP
4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF), which acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Learn MoreStarting at: $105.00
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KL 001
KL 001 is a cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Learn MoreStarting at: $119.00
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JW 67
JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Learn MoreStarting at: $109.00
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17-DMAG hydrochloride
17-DMAG hydrochloride is a water-soluble analog of 17-AAG and geldanamycin, which binds the ATP binding site of Hsp90 and inhibits its chaperone activity, and displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively). Learn MoreStarting at: $159.00
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Pyrrolidinedithiocarbamate ammonium
This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP. Learn MoreStarting at: $65.00
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Withaferin A
Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. It prevents NF-κB activation by inhibiting activation of IKKβ. Learn MoreStarting at: $90.00
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NAADP tetrasodium salt
NAADP tetrasodium salt initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation and also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER). Learn MoreStarting at: $219.00
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Ionomycin free acid
Ionomycin is a calcium ionophore. Learn MoreStarting at: $99.00
