Enzyme-Linked Receptors

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  • Ro 26-4550 trifluoroacetate

    Ro 26-4550 trifluoroacetate is a competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC50 = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Learn More

    Starting at: $189.00

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  • YM 90709

    S-Sulfo-L-cysteine sodium salt is an EAA receptor agonist. Learn More

    Starting at: $140.00

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  • A 83-01

    A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 . Learn More

    Starting at: $135.00

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  • A 286982

    A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC50 values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively). Learn More

    Starting at: $139.00

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  • TCS 2314

    Integrin very late antigen-4 (VLA-4; α4β1) antagonist (IC50 = 4.4 nM), which blocks the activation of inflammatory cells. Learn More

    Starting at: $139.00

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  • RWJ 50271

    CI 1020 is a highly selective, orally active, non-peptide endothelin-A receptor (ETA) antagonist (IC50 values are 0.3 and 480 nM for ETA and ETB receptors respectively). Learn More

    Starting at: $135.00

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  • GR 144053 trihydrochloride

    GR 144053 trihydrochloride is a potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC50 = 37 nM). Learn More

    Starting at: $110.00

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  • TC-I 15

    TC-I 15 is a potent α2β1 integrin inhibitor. IC50 values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively. Learn More

    Starting at: $169.00

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  • 7,8-Dihydroxyflavone

    7,8-Dihydroxyflavone is a tyrosine kinase receptor B (TrkB) agonist that binds to the extracellular domain of the receptor (Kd = 320 nM). It inhibits glutamate-triggered apoptosis in hippocampal neurons in vitro and in vivo. Learn More

    Starting at: $119.00

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  • Ro 08-2750

    Ro 08-2750 is a non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 μM) possibly causing a conformational change, which inhibits binding selectively to p75NTR at submicromolar concentrations and to both p75NTR and TrkA at higher concentrations (> 5 μM). Learn More

    Starting at: $69.00

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  • Alantolactone

    Alantolactone induces activin/SMAD3 signaling and disrupts Cripto-1/activin receptor type II A interaction and displays antiproliferative activity in human colon adenocarcinoma HCT-8 cells. Learn More

    Starting at: $125.00

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  • LM 22A4

    LM 22A4 is a potent tropomyosin-related kinase B (TrkB) agonist (IC50 = 47 nM), which induces activation of Trk, Akt and ERK in mouse hippocampus and striatum. Reverses deficits in motor task learning in mice following traumatic brain injury; restores respiratory function in a rat model of Rett syndrome. Learn More

    Starting at: $129.00

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  • ANA 12

    ANA 12 is a TrkB receptor antagonist, which demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Learn More

    Starting at: $135.00

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  • BDNF (human)

    BDNF (human) is a member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors which enhances the survival, growth and differentiation of neurons. Learn More

    Starting at: $239.00

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  • GW 441756

    GW 441756 is a potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM), whih displays > 100-fold selectivity over a range of other kinases. Learn More

    Starting at: $139.00

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  • PF 04217903 mesylate

    PF 04217903 mesylate is a highly selective, high affinity c-Met inhibitor that displays >1000-fold selectivity for c-Met over a panel of 208 kinases. Learn More

    Starting at: $189.00

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  • GTP 14564

    GTP 14564 is a potent, selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Learn More

    Starting at: $99.00

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  • Poly(I:C)

    Poly(I:C) is a synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Learn More

    Starting at: $79.00

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  • Resiquimod

    Resiquimod is a toll-like receptor 7 (TLR7) agonist which induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs), and inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Learn More

    Starting at: $50.00

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  • CU CPT 22

    CU CPT 22 is a selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM), which inhibits the release of proinflammatory cytokines TNF-α and IL-1β. Learn More

    Starting at: $155.00

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