Phosphodiesterases

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  • Pentoxifylline

    Pentoxifylline is a phosphodiesterase inhibitor that blocks production of TNF-&alpha and other cytokines. Learn More

    Starting at: $69.00

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  • BRL 50481

    BRL 50481 is a selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM), which displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5. Learn More

    Starting at: $89.00

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  • Etazolate hydrochloride

    Etazolate hydrochloride is a phosphodiesterase inhibitor, selective for PDE4 (IC50 = 2.0 μM). Learn More

    Starting at: $79.00

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  • CDP 840 hydrochloride

    (S)-3,5-DHPG is a selective group I mGlu receptor agonist. Learn More

    Starting at: $135.00

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  • BC 11-38

    BC 11-38 is a selective phosphodiesterase (PDE) 11 inhibitor that elevates cAMP levels and cortisol production in H295R human adenocarcinoma cells. Learn More

    Starting at: $129.00

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  • Enoximone

    Enoximone is increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Learn More

    Starting at: $119.00

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  • MMPX

    MMPX is a specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase. Learn More

    Starting at: $119.00

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  • MY-5445

    MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase. Learn More

    Starting at: $89.00

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  • Trequinsin hydrochloride

    Trequinsin hydrochloride is an extremely potent inhibitor of cGMP-inhibited phosphodiesterase that inhibits arachidonic acid-induced aggregation of human platelets. Learn More

    Starting at: $199.00

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  • Irsogladine maleate

    Irsogladine maleate is a phosphodiesterase 4 (PDE4) inhibitor that prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Learn More

    Starting at: $99.00

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  • Gisadenafil besylate

    Gisadenafil besylate is a PDE5 inhibitor. Learn More

    Starting at: $159.00

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  • T 0156 hydrochloride

    T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Learn More

    Starting at: $139.00

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  • Siguazodan

    Siguazodan is a phosphodiesterase inhibitor, selective for PDE3 (IC50 = 117 nM). Learn More

    Starting at: $100.00

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  • CP 80633

    CP 80633 is a selective inhibitor of phosphodiesterase type 4 (IC50 values are 1.9, > 100, > 100, > 100 and > 100 μM for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Learn More

    Starting at: $135.00

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  • Piclamilast

    Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils) which displays >19,000-fold selectivity over other PDE isoenzymes. Learn More

    Starting at: $140.00

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  • RS 25344 hydrochloride

    RS 25344 hydrochloride is a potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro. Learn More

    Starting at: $115.00

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  • Mesopram

    Mesopram is an orally active phosphodiesterase (PDE) 4 inhibitor which inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Learn More

    Starting at: $135.00

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  • YM 976

    YM 976 is an orally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration. Learn More

    Starting at: $98.00

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  • ICI 63197

    ICI 63197 is a potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Learn More

    Starting at: $99.00

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  • IBMX

    IBMX is a phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively) which suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Learn More

    Starting at: $59.00

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