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Cyclases
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NKH 477
NKH 477 is a water-soluble analog of forskolin that is a potent activator of adenylyl cyclase which shows some selectivity for cardiac (type V) adenylyl cyclase. Learn MoreStarting at: $150.00
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MDL 12330A hydrochloride
MDL 12330A hydrochloride is an inhibitor of adenylyl cyclase, which also inhibits cAMP and cGMP phosphodiesterases, and blocks slow extracellular and store-operated Ca2+ entry into cells. Learn MoreStarting at: $85.00
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KH 7
KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo), which inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM, and locks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM. Learn MoreStarting at: $109.00
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1,9-Dideoxyforskolin
1,9-Dideoxyforskolin is an inactive analog of forskolin. Learn MoreStarting at: $58.00
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SQ 22536
SQ 22536 is an inhibitor of adenylyl cyclase (IC50 = 1.4 μM) which inhibits PGE1-stimulated increases in cAMP levels in intact human platelets. Learn MoreStarting at: $98.00
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CFM 1571 hydrochloride
CFM 1571 hydrochloride is a soluble guanylyl cyclase (sGC) activator (EC50 = 5.49 μM), which inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM). Learn MoreStarting at: $149.00
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BAY 41-2272
BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC)which acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit and inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Learn MoreStarting at: $139.00
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NS 2028
NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM), which inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC). Learn MoreStarting at: $139.00
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A 350619 hydrochloride
A 350619 hydrochloride is activates basal sGC and synergistically activates sGC in the presence of NO. Learn MoreStarting at: $129.00
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BPIPP
BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor, which downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). It also inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo. Learn MoreStarting at: $145.00
