ECM & Adhesion Molecules

16 Item(s)

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  • KF 38789

    KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Learn More

    Starting at: $135.00

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  • ARP 101

    ARP 101 is a selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1. Learn More

    Starting at: $115.00

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  • ARP 100

    ARP 100 is a selective inhibitor of MMP-2 (IC50 = 12 nM) with selectivity over MMP-9, MMP-3, MMP-1 and MMP-7. Learn More

    Starting at: $99.00

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  • WAY 170523

    WAY 170523 is a potent and selective inhibitor of MMP-13 (IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively). Learn More

    Starting at: $79.00

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  • GI 254023X

    GI 254023X is a selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17. Learn More

    Starting at: $119.00

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  • Doxycycline hyclate

    Doxycycline hyclate is a broad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Learn More

    Starting at: $80.00

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  • UK 370106

    UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Learn More

    Starting at: $155.00

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  • UK 356618

    UK 356618 is a potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM), which displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively). Learn More

    Starting at: $189.00

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  • ONO 4817

    ONO 4817 is a broad spectrum MMP inhibitor; Ki values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC50 = 1600 nM for MMP-1). It exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma. Learn More

    Starting at: $189.00

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  • CP 471474

    CP 471474 is a broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Learn More

    Starting at: $95.00

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  • PD 166793

    PD 166793 is a broad spectrum MMP inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure. Learn More

    Starting at: $90.00

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  • Ro 32-3555

    Ro 32-3555 is a potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively) which inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Learn More

    Starting at: $175.00

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  • H 1152 dihydrochloride

    H 1152 dihydrochloride is a rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μM for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Learn More

    Starting at: $139.00

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  • SB 772077B dihydrochloride

    SB 772077B dihydrochloride is a potent Rho-kinase (ROCK) inhibitor with a IC50 value of approximately 5.6 nM at recombinant human ROCK1 and 2. Learn More

    Starting at: $195.00

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  • Y-27632 dihydrochloride

    Y-27632 dihydrochloride is a selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and > 250 μM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Learn More

    Starting at: $60.00

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  • HA 1100 hydrochloride

    HA 1100 hydrochlorid is a cell-permeable active metabolite of Fasudil, which also inhibits neutrophil migration and produces potent vasodilatory effects in vivo. Learn More

    Starting at: $135.00

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16 Item(s)

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