Potassium Channels

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  • NS 5806

    NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito), which increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM), and inhibits KV1.4-mediated currents independently of KChIP2. Learn More

    Starting at: $149.00

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  • CP 339818 hydrochloride

    CP 339818 hydrochloride is a potent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM), which inhibits KV1.4 with an IC50 of ~ 300 nM. Learn More

    Starting at: $120.00

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  • (-)-[3R,4S]-Chromanol 293B

    680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) (Ki = 51 nM) which exhibits no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors. Learn More

    Starting at: $140.00

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  • Chromanol 293B

    (-)-[3R,4S]-Chromanol 293B is an enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Learn More

    Starting at: $135.00

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  • ML 213

    ML 213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively), which displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Learn More

    Starting at: $119.00

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  • PD 118057

    PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator, which displays no major effect on INa, ICa/L, IK1 and IKs currents. Learn More

    Starting at: $119.00

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  • ICA 110381

    ICA 110381 is a KV7.2/7.3 activator (EC50 = 0.38 μM), which decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures. Learn More

    Starting at: $99.00

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  • 4-Aminopyridine

    4-Aminopyridine is a non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Learn More

    Starting at: $55.00

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  • NS 3623

    NS 3623 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator, which activates the IKr current and displays antiarrhythmic activity and exhibits potential dual mode of action at the hERG inhibitory site; may also act as a partial blocker of KV11.1 (hERG) channels. Learn More

    Starting at: $145.00

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  • NS 1643

    NS 1643 is a human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM), which exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Learn More

    Starting at: $90.00

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  • DPO-1

    DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5), which displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Learn More

    Starting at: $105.00

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  • Tetraethylammonium chloride

    Tetraethylammonium chloride is a non-selective K+ channel blocker. Learn More

    Starting at: $39.00

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  • AM 92016 hydrochloride

    AM 92016 hydrochloride is a specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity which exhibits proarrhythmic and prohypertensive activity in vivo. Learn More

    Starting at: $110.00

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  • ICA 069673

    ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) potassium channel opener with EC50 of 0.69 μM. Learn More

    Starting at: $119.00

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  • L-364,373

    L-364,373 is a activator of KV7.1 (KCNQ1) channels. Learn More

    Starting at: $140.00

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  • Linopirdine dihydrochloride

    Linopirdine dihydrochloride is a blocker of KV7 (KCNQ) voltage-gated potassium channels; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM). Learn More

    Starting at: $115.00

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  • XE 991 dihydrochloride

    XE 991 dihydrochloride is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. Blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). Learn More

    Starting at: $110.00

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  • RuBi-4AP

    RuBi-4AP is a water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Learn More

    Starting at: $119.00

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  • JNJ 303

    JNJ 303 is a potent IKs blocker with an IC50 of 64 nM. Learn More

    Starting at: $125.00

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  • UK 78282 hydrochloride

    UK 78282 hydrochloride is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Learn More

    Starting at: $135.00

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