Inward Rectifier Potassium (Kir) Channels
-
ML 133 hydrochloride
ML 133 hydrochloride is a selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Learn MoreStarting at: $85.00
-
Cromakalim
Cromakalim is a prototypical Kir6 (KATP) channel opener that relaxes rabbit isolated portal vein with an IC50 value of 21 nM . Learn MoreStarting at: $139.00
-
P1075
P1075 is a potent Kir6 (KATP) channel opener that binds to SUR2A and SUR2B with high affinity with Kd values of 17 and 3 nM respectively. Learn MoreStarting at: $139.00
-
PNU 37883 hydrochloride
PNU 37883 hydrochloride acts as a novel antagonist selective for the vascular form of Kir6 (KATP) channel. It inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Learn MoreStarting at: $125.00
-
VU 590 dihydrochloride
VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM), which also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Learn MoreStarting at: $85.00
-
ZM 226600
ZM 226600 is a potent Kir6 (KATP) channel opener (EC50 = 0.5 μM), devoid of antiandrogen properties. Learn MoreStarting at: $95.00
-
VU 591 hydrochloride
VU 591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Learn MoreStarting at: $100.00
-
Y-26763
Y-26763 is a kir6 (KATP) channel opener and active metabolite of Y-27152, which relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Learn MoreStarting at: $130.00
-
Y-27152
Y-27152 is a prodrug of the Kir6 (KATP) channel opener Y-26763, which produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals. Learn MoreStarting at: $130.00
-
Levcromakalim
Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim. Learn MoreStarting at: $169.00