Inward Rectifier Potassium (Kir) Channels

10 Item(s)

per page

  • ML 133 hydrochloride

    ML 133 hydrochloride is a selective blocker of inwardly rectifying Kir2 potassium channels (IC50 values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mKir2.1, hKir2.6, hKir2.2 and hKir2.3 respectively). Learn More

    Starting at: $85.00

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  • Cromakalim

    Cromakalim is a prototypical Kir6 (KATP) channel opener that relaxes rabbit isolated portal vein with an IC50 value of 21 nM . Learn More

    Starting at: $139.00

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  • P1075

    P1075 is a potent Kir6 (KATP) channel opener that binds to SUR2A and SUR2B with high affinity with Kd values of 17 and 3 nM respectively. Learn More

    Starting at: $139.00

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  • PNU 37883 hydrochloride

    PNU 37883 hydrochloride acts as a novel antagonist selective for the vascular form of Kir6 (KATP) channel. It inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Learn More

    Starting at: $125.00

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  • VU 590 dihydrochloride

    VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM), which also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Learn More

    Starting at: $85.00

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  • ZM 226600

    ZM 226600 is a potent Kir6 (KATP) channel opener (EC50 = 0.5 μM), devoid of antiandrogen properties. Learn More

    Starting at: $95.00

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  • VU 591 hydrochloride

    VU 591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Learn More

    Starting at: $100.00

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  • Y-26763

    Y-26763 is a kir6 (KATP) channel opener and active metabolite of Y-27152, which relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Learn More

    Starting at: $130.00

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  • Y-27152

    Y-27152 is a prodrug of the Kir6 (KATP) channel opener Y-26763, which produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals. Learn More

    Starting at: $130.00

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  • Levcromakalim

    Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim. Learn More

    Starting at: $169.00

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10 Item(s)

per page