Ion Pumps/Transporters

12 Item(s)

per page

  • Paxilline

    Paxilline, a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels, binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Learn More

    Starting at: $198.00

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  • Ochratoxin A

    Ochratoxin A is a mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump which induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Learn More

    Starting at: $69.00

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  • SCH 28080

    SCH 28080 is a potent inhibitor of H+,K+-ATPase that binds to the K+ recognition site and is competitive with respect to K+. Learn More

    Starting at: $139.00

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  • Concanamycin A

    Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. Learn More

    Starting at: $99.00

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  • YM 244769

    YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX) that inhibits Na+-dependent 45Ca2+ uptake with IC50 values of 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively. Learn More

    Starting at: $125.00

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  • SN-6

    SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor which displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Learn More

    Starting at: $115.00

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  • Benzamil

    Talampanel is a non-competitive AMPA/kainate receptor antagonist that displays 2.3-3-fold more potent activity than GYKI 52466 . Learn More

    Starting at: $50.00

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  • CGP 37157

    CGP 37157 is a selective antagonist of the mitochondrial Na+-Ca2+ exchanger with an IC50 of 0.4 μM. Learn More

    Starting at: $139.00

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  • Zoniporide dihydrochloride

    Zoniporide dihydrochloride is a sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Learn More

    Starting at: $140.00

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  • Lithium carbonate

    Lithium carbonate is thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Learn More

    Starting at: $29.00

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  • N2-Methyl-L-arginine

    N2-Methyl-L-arginine is a selective L-arginine uptake inhibitor (Ki = 500 μM) which inhibits uptake of arginine by the lysosomal system c in human fibroblast in vitro. Learn More

    Starting at: $119.00

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  • VU 0240551

    VU 0240551 is an inhibitor of the neuronal K-Cl cotransporter, KCC2 that also inhibits hERG and L-type Ca2+ channels. Learn More

    Starting at: $115.00

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12 Item(s)

per page