Guanylyl Cyclase

NS 2028

NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM), which inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC). Learn More

Starting at: $139.00

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BAY 41-2272

BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC)which acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit and inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Learn More

Starting at: $139.00

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CFM 1571 hydrochloride

CFM 1571 hydrochloride is a soluble guanylyl cyclase (sGC) activator (EC50 = 5.49 μM), which inhibits collagen-stimulated platelet aggregation in vitro (IC50 = 2.84 μM). Learn More

Starting at: $149.00

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BPIPP

BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor, which downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). It also inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo. Learn More

Starting at: $145.00

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A 350619 hydrochloride

A 350619 hydrochloride is activates basal sGC and synergistically activates sGC in the presence of NO. Learn More

Starting at: $129.00

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