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Signal Transduction
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CCG 50014
CCG 50014 is a potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein that exhibits >20-fold selectivity for RGS4 over other RGS proteins. Learn MoreStarting at: $125.00
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SecinH3
SecinH3 is a sec7-specific GEF inhibitor that inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation. Learn MoreStarting at: $169.00
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SCH 202676 hydrobromide
SCH 202676 hydrobromide is a sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors that inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors IC50 values of 0.1-1.8 μM. Learn MoreStarting at: $115.00
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8-Bromo-cGMP, sodium salt
Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. Learn MoreStarting at: $55.00
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Gue 1654
Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator, which selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Learn MoreStarting at: $90.00
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Gallein
Gallein is an inhibitor of G protein βγ subunit-dependent signaling, which blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells. Learn MoreStarting at: $55.00
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CCG 2046
CCG 2046 is an inhibitor of regulator of G-protein signaling 4 (RGS4), which reduces the RGS4-Gαo protein-protein interaction signal. Learn MoreStarting at: $90.00
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SD 1008
SD 1008 is a JAK2/STAT3 signaling pathway inhibitor, which inhibits activation of STAT3, JAK2 and Src. Learn MoreStarting at: $109.00
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MDL 28170
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B that rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Learn MoreStarting at: $65.00
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Calpeptin
Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Learn MoreStarting at: $90.00
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Carbenoxolone disodium
Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. Learn MoreStarting at: $65.00
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SR 11302
SB 205384 is a GABAA receptor modulator; slows current decay. Learn MoreStarting at: $110.00
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HPI 1
HPI 1, a Hedgehog (Hh) signaling inhibitor, inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells with IC50 values of 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation. Learn MoreStarting at: $129.00
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20(S)-Hydroxycholesterol
20(S)-Hydroxycholesterol is a allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein that activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). Learn More -
Jervine
Jervine is an inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM), which binds directly to Smoothened (Smo), and inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Learn MoreStarting at: $159.00
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AY 9944 dihydrochloride
AY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms, which inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. Learn MoreStarting at: $119.00
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SANT-2
SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM), which displays allosteric binding characteristics similar to SANT-1. Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively). Learn MoreStarting at: $139.00
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U 18666A
U 18666A is an inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Learn MoreStarting at: $139.00
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Ciliobrevin A
Ciliobrevin A is a hedgehog (Hh) pathway antagonist which blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Learn MoreStarting at: $119.00
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MG 132
MG 132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM) which inhibits TNF-α-induced NF-κB activation and IκBα degradation. Learn MoreStarting at: $75.00
