Enzymes

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  • Fumonisin B1

    Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme, which potently inhibits sphingosine N-acyltransferase (ceramide synthase) and inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively. Learn More

    Starting at: $70.00

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  • EB 47

    EB 47 is a potent inhibitor of PARP-1 (IC50 = 45 nM), which reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model. Learn More

    Starting at: $145.00

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  • Topotecan hydrochloride

    Topotecan hydrochloride is a DNA topoisomerase I inhibitor which induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Learn More

    Starting at: $45.00

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  • HA 130

    HA 130 is a selective autotaxin inhibitor (IC50 = 28 nM), which binds and inhibits autotaxin reversibly. Learn More

    Starting at: $135.00

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  • Banoxantrone dihydrochloride

    Banoxantrone dihydrochloride is a bioreductive prodrug which activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Learn More

    Starting at: $125.00

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  • VULM 1457

    Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor which decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats. Learn More

    Starting at: $119.00

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  • PD 150606

    PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Learn More

    Starting at: $100.00

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  • U 104

    Potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells) which inhibits tumor metastasis in the rat 4T1 metastasis model. Learn More

    Starting at: $50.00

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  • SQ 22536

    SQ 22536 is an inhibitor of adenylyl cyclase (IC50 = 1.4 μM) which inhibits PGE1-stimulated increases in cAMP levels in intact human platelets. Learn More

    Starting at: $98.00

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  • NKH 477

    NKH 477 is a water-soluble analog of forskolin that is a potent activator of adenylyl cyclase which shows some selectivity for cardiac (type V) adenylyl cyclase. Learn More

    Starting at: $150.00

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  • YM 750

    YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM) which exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo. Learn More

    Starting at: $95.00

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  • (S)-Methylisothiourea sulfate

    (S)-Methylisothiourea sulfate is a highly selective, potent competitive inhibitor of iNOS. Learn More

    Starting at: $79.00

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  • Xanthohumol

    Xanthohumol is a Valosin-containing protein (VCP) inhibitor that binds to the N domain of VCP, suppressing function and impairing autophagosome maturation. Learn More

    Starting at: $139.00

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  • BYK 191023 dihydrochloride

    BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) that acts in an NADPH- and time-dependent manner. Learn More

    Starting at: $119.00

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  • S-Isopropylisothiourea hydrobromide

    S-Isopropylisothiourea hydrobromide is a potent inhibitor of NO synthase, with selectivity for the inducible form. Learn More

    Starting at: $69.00

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  • 2-Iminopiperidine hydrochloride

    SR 11302 is an inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Learn More

    Starting at: $70.00

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  • AR-C 102222

    AR-C 102222 is an inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC50 values are 0.037 and >100 μM for iNOS and eNOS respectively) and exhibits antinociceptive and anti-inflammatory activity in rodent pain models. Learn More

    Starting at: $159.00

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  • AMT hydrochloride

    AMT hydrochloride is a potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM). Learn More

    Starting at: $85.00

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  • Aminoguanidine hydrochloride

    Aminoguanidine hydrochloride is an irreversible inhibitor of iNOS that displays some selectivity over eNOS and nNOS. Learn More

    Starting at: $65.00

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  • 1400W dihydrochloride

    1400W dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM) which is selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Learn More

    Starting at: $100.00

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