Raf Kinase

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  • SB 590885

    SB 590885 is a potent B-Raf inhibitor (Kd = 0.3 nM), which is elective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively), and decreases anchorage-independent growth of melanoma cell lines. It also inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. Learn More

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