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Checkpoint Kinase
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DIM
DIM is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines, which inhibits phosphorylation of EGFR and downstream activation of ERK. Learn MoreStarting at: $39.00
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SB 218078
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Learn MoreStarting at: $85.00
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PD 407824
PD 407824 is a selective inhibitor of checkpoint kinases Chk1 and Wee1 with IC50 values of 47 and 97 nM respectively. Learn MoreStarting at: $79.00
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NSC 109555 ditosylate
NSC 109555 ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor that displays no effect on a range of other kinases including Chk1. Learn MoreStarting at: $119.00
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TCS 2312
TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor that enhances the cell killing activity of Gemcitabine in breast and prostate cancer cell lines and displays antiproliferative effects in vitro. Learn MoreStarting at: $139.00
