Enzymes

Items 1 to 20 of 337 total

per page

Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5
  • CPT 11

    CPT 11 is an inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Learn More

    Starting at: $139.00

    View Details

  • S 32826

    S 32826 is an inhibitor of autotaxin (IC50 = 9 nM), which displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ)and inhibits LPA release from adipocytes (IC50 = 90 nM). Learn More

    Starting at: $135.00

    View Details

  • BYK 204165

    BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). Learn More

    Starting at: $95.00

    View Details

  • CI 976

    CI 976 is a selective acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.073 μM), which inhibits Golgi-associated LPL acyltransferase (LPAT) activity (IC50 = 15 μM). Learn More

    Starting at: $95.00

    View Details

  • Fumonisin B1

    Fumonisin B1 is a mycotoxin produced by Fusarium moniliforme, which potently inhibits sphingosine N-acyltransferase (ceramide synthase) and inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively. Learn More

    Starting at: $70.00

    View Details

  • EB 47

    EB 47 is a potent inhibitor of PARP-1 (IC50 = 45 nM), which reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model. Learn More

    Starting at: $145.00

    View Details

  • Topotecan hydrochloride

    Topotecan hydrochloride is a DNA topoisomerase I inhibitor which induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Learn More

    Starting at: $45.00

    View Details

  • HA 130

    HA 130 is a selective autotaxin inhibitor (IC50 = 28 nM), which binds and inhibits autotaxin reversibly. Learn More

    Starting at: $135.00

    View Details

  • Banoxantrone dihydrochloride

    Banoxantrone dihydrochloride is a bioreductive prodrug which activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Learn More

    Starting at: $125.00

    View Details

  • YM 750

    YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50 = 0.18 μM) which exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo. Learn More

    Starting at: $95.00

    View Details

  • NKH 477

    NKH 477 is a water-soluble analog of forskolin that is a potent activator of adenylyl cyclase which shows some selectivity for cardiac (type V) adenylyl cyclase. Learn More

    Starting at: $150.00

    View Details

  • SQ 22536

    SQ 22536 is an inhibitor of adenylyl cyclase (IC50 = 1.4 μM) which inhibits PGE1-stimulated increases in cAMP levels in intact human platelets. Learn More

    Starting at: $98.00

    View Details

  • U 104

    Potent carbonic anhydrase (CA) inhibitor (Ki values are 4.5, 45.1, 5080 and 9640 nM for CA XII, CA IX, CA I and CA II respectively in MDA-MB-231 cells) which inhibits tumor metastasis in the rat 4T1 metastasis model. Learn More

    Starting at: $50.00

    View Details

  • PD 150606

    PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Learn More

    Starting at: $100.00

    View Details

  • VULM 1457

    Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor which decreases cholesterol levels in the plasma and liver of diabetic-hypercholesterolemic rats. Learn More

    Starting at: $119.00

    View Details

  • Dexrazoxane hydrochloride

    Dexrazoxane hydrochloride is a topoisomerase II inhibitor and intracellular ion chelator, which bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Learn More

    Starting at: $45.00

    View Details

  • DR 2313

    DR 2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Learn More

    Starting at: $49.00

    View Details

  • Ceranib 1

    Ceranib 1 is a ceramidase inhibitor which inhibits proliferation in SKOV3 ovarian carcinoma cells (IC50 = 3.9 μM), and induces accumulation of ceramide species and decreases sphingosine and sphingosine-1-phosphate (S1P) levels in SKOV3 cells. Learn More

    Starting at: $85.00

    View Details

  • TC HSD 21

    TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 values are 6 and 40 nM at human and mouse 17β-HSD3 respectively). Learn More

    Starting at: $109.00

    View Details

  • KH 7

    KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo), which inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM, and locks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM. Learn More

    Starting at: $109.00

    View Details

Items 1 to 20 of 337 total

per page

Page:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5