Ion Channels

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  • Mexiletine hydrochloride

    Mexiletine hydrochloride is an use-dependent sodium channel blocker (IC50 values are 75.3 and 23.6 μM for tonic and use-dependent block respectively). Learn More

    Starting at: $49.00

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  • RN 1747

    RN 1747 is a selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively) which displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Learn More

    Starting at: $95.00

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  • L-364,373

    L-364,373 is a activator of KV7.1 (KCNQ1) channels. Learn More

    Starting at: $140.00

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  • Linopirdine dihydrochloride

    Linopirdine dihydrochloride is a blocker of KV7 (KCNQ) voltage-gated potassium channels; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM). Learn More

    Starting at: $115.00

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  • OLDA

    OLDA is a potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC50 = 36 nM at hVR1) with low affinity for rCB1 receptors (Ki = 1.6 μM). Learn More

    Starting at: $75.00

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  • Efonidipine hydrochloride monoethanolate

    Efonidipine hydrochloride monoethanolate is a selective blocker of L-type and T-type Ca2+ channels which displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. Learn More

    Starting at: $85.00

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  • Ruthenium Red

    Ruthenium Red Blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release. Learn More

    Starting at: $65.00

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  • Amlodipine besylate

    Amlodipine besylate is a L-type calcium channel blocker that displays antihypertensive properties, which inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Learn More

    Starting at: $50.00

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  • FPL 64176

    FPL 64176 is a potent activator of L-type Ca2+ channels (EC50 = 16 nM). Learn More

    Starting at: $85.00

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  • TC-N 1752

    TC-N 1752 is a selective blocker of human NaV1.7 channels (IC50 values are 0.17, 0.3, 0.4 and 1.1 μM at hNaV1.7, hNaV1.3, hNaV1.4 and hNaV1.5 respectively), which also displays analgesic efficacy in the formalin pain model and inhibits tetrodotoxin-sensitive sodium channels. Learn More

    Starting at: $155.00

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  • SR 33805 oxalate

    SR 33805 oxalate is a potent Ca2+ channel antagonist which binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. It also inhibits PDGF-stimulated smooth muscle cell proliferation. Learn More

    Starting at: $150.00

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  • XE 991 dihydrochloride

    XE 991 dihydrochloride is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. Blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). Learn More

    Starting at: $110.00

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  • A 887826

    A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Learn More

    Starting at: $135.00

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  • Sipatrigine

    Sipatrigine is a blocker of voltage-dependent sodium channels (NaV) which inhibits glutamate release and displays neuroprotective activity in rat models of cerebral ischemia. Learn More

    Starting at: $145.00

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  • Lercanidipine hydrochloride

    Lercanidipine hydrochloride is a L-type Ca2+ channel blocker that displays higher vascular selectivity than felodipine Learn More

    Starting at: $75.00

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  • ML 218 hydrochloride

    ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC50 values are 270 and 310 nM for Cav3.3 and Cav3.2 respectively in a patch EP assay). Learn More

    Starting at: $169.00

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  • PALDA

    PALDA is an endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Learn More

    Starting at: $75.00

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  • UK 78282 hydrochloride

    UK 78282 hydrochloride is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Learn More

    Starting at: $135.00

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  • PPAHV

    PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki = 3.1 μM) that displays non-cooperative binding and induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo. Learn More

    Starting at: $98.00

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  • AM 92016 hydrochloride

    AM 92016 hydrochloride is a specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity which exhibits proarrhythmic and prohypertensive activity in vivo. Learn More

    Starting at: $110.00

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