Ion Channels
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FPL 64176
FPL 64176 is a potent activator of L-type Ca2+ channels (EC50 = 16 nM). Learn MoreStarting at: $85.00
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ML 213
ML 213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively), which displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Learn MoreStarting at: $119.00
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α-Spinasterol
α-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM), which reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Learn MoreStarting at: $89.00
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A 887826
A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). Learn MoreStarting at: $135.00
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SB 366791
SB 366791 is a potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Learn MoreStarting at: $109.00
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SB 452533
SB 452533 is a potent TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Learn MoreStarting at: $109.00
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NS 1643
NS 1643 is a human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM), which exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Learn MoreStarting at: $90.00
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DPO-1
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5), which displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Learn MoreStarting at: $105.00
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Vinpocetine
Vinpocetine is a phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM), which also blocks voltage-gated Na+ channels. Learn MoreStarting at: $109.00
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Sipatrigine
Sipatrigine is a blocker of voltage-dependent sodium channels (NaV) which inhibits glutamate release and displays neuroprotective activity in rat models of cerebral ischemia. Learn MoreStarting at: $145.00
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NS 5806
NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito), which increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM), and inhibits KV1.4-mediated currents independently of KChIP2. Learn MoreStarting at: $149.00
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4-Aminopyridine
4-Aminopyridine is a non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Learn MoreStarting at: $55.00
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TC-N 1752
TC-N 1752 is a selective blocker of human NaV1.7 channels (IC50 values are 0.17, 0.3, 0.4 and 1.1 μM at hNaV1.7, hNaV1.3, hNaV1.4 and hNaV1.5 respectively), which also displays analgesic efficacy in the formalin pain model and inhibits tetrodotoxin-sensitive sodium channels. Learn MoreStarting at: $155.00
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SR 33805 oxalate
SR 33805 oxalate is a potent Ca2+ channel antagonist which binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. It also inhibits PDGF-stimulated smooth muscle cell proliferation. Learn MoreStarting at: $150.00
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Tetraethylammonium chloride
Tetraethylammonium chloride is a non-selective K+ channel blocker. Learn MoreStarting at: $39.00
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AMG 9810
AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Learn MoreStarting at: $119.00
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Flecainide acetate
Flecainide acetate is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Learn MoreStarting at: $45.00
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5'-Iodoresiniferatoxin
5'-Iodoresiniferatoxin is a potent and silent vanilloid receptor antagonist that binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a Ki of 5.8 nM. Learn MoreStarting at: $269.00
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XE 991 dihydrochloride
XE 991 dihydrochloride is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels. Blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). Learn MoreStarting at: $110.00
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(-)-[3R,4S]-Chromanol 293B
680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) (Ki = 51 nM) which exhibits no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors. Learn MoreStarting at: $140.00