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Ion Channels
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ML 298 hydrochloride
ML 298 hydrochloride is a selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively), which decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability. Learn MoreStarting at: $125.00
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AMG 9810
AMG 9810 is a potent and selective, competitive vanilloid TRPV1 receptor antagonist (IC50 = 17 nM). Learn MoreStarting at: $119.00
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Flecainide acetate
Flecainide acetate is an open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Learn MoreStarting at: $45.00
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5'-Iodoresiniferatoxin
5'-Iodoresiniferatoxin is a potent and silent vanilloid receptor antagonist that binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a Ki of 5.8 nM. Learn MoreStarting at: $269.00
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![(-)-[3R,4S]-Chromanol 293B](https://www.emmx.com/media/catalog/product/cache/1/small_image/295x/040ec09b1e35df139433887a97daa66f/images/catalog/product/placeholder/small_image.jpg)
(-)-[3R,4S]-Chromanol 293B
680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) (Ki = 51 nM) which exhibits no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors. Learn MoreStarting at: $140.00
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Chromanol 293B
(-)-[3R,4S]-Chromanol 293B is an enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Learn MoreStarting at: $135.00
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4-Aminopyridine
4-Aminopyridine is a non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Learn MoreStarting at: $55.00
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ML 213
ML 213 is a selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively), which displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. Learn MoreStarting at: $119.00
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α-Spinasterol
α-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM), which reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Learn MoreStarting at: $89.00
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SB 366791
SB 366791 is a potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Learn MoreStarting at: $109.00
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SB 452533
SB 452533 is a potent TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Learn MoreStarting at: $109.00
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NS 1643
NS 1643 is a human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM), which exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Learn MoreStarting at: $90.00
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DPO-1
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5), which displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Learn MoreStarting at: $105.00
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Vinpocetine
Vinpocetine is a phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM), which also blocks voltage-gated Na+ channels. Learn MoreStarting at: $109.00
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NS 5806
NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito), which increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM), and inhibits KV1.4-mediated currents independently of KChIP2. Learn MoreStarting at: $149.00
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BCTC
BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist, which inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Learn MoreStarting at: $109.00
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Tetraethylammonium chloride
Tetraethylammonium chloride is a non-selective K+ channel blocker. Learn MoreStarting at: $39.00
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ICA 069673
ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) potassium channel opener with EC50 of 0.69 μM. Learn MoreStarting at: $119.00
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Olvanil
Olvanil, a potent vanilloid receptor agonist, blocks anandamide uptake (IC50 = 9 μM) and may bind to CB1 cannabinoid receptors. Learn MoreStarting at: $99.00
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L-651,582
L-651,582 is an orally active Ca2+ channel blocker which inhibits K+- and carbachol-stimulated Ca2+ influx (IC50 values are 500 and 935 nM respectively). Learn MoreStarting at: $149.00
