Transporters
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STF 31
STF 31 is an inhibitor of GLUT1 that inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells. Learn MoreStarting at: $155.00
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Guvacine hydrochloride
Guvacine hydrochloride is a specific GABA uptake inhibitor. IC50 values are 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. Learn MoreStarting at: $125.00
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NNC 711
NNC 711 is a potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Learn MoreStarting at: $135.00
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Tiagabine hydrochloride
Tiagabine hydrochloride is a GABA uptake inhibitor (IC50 = 67 nM in vivo), which exhibits high affinity and selectivity for the GAT-1 GABA transporter. Learn MoreStarting at: $169.00
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Paxilline
Paxilline, a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels, binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Learn MoreStarting at: $198.00
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Ochratoxin A
Ochratoxin A is a mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump which induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Learn MoreStarting at: $69.00
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CI 966 hydrochloride
CI 966 hydrochloride is a selective inhibitor of the GABA transporter GAT-1 (IC50 values are 0.26 and 1.2 μM at cloned human and rat GAT-1 respectively). Learn MoreStarting at: $120.00
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(±)-Nipecotic acid
(±)-Nipecotic acid is a GABA uptake inhibitor with IC50 values of 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. Learn MoreStarting at: $56.00
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NNC 05-2090 hydrochloride
NNC 05-2090 hydrochloride is a GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (Ki values are 1.4, 15, 19 and 41 μM for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Learn MoreStarting at: $140.00
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(S)-SNAP 5114
BTS is a selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM), reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle. Learn MoreStarting at: $135.00
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SCH 28080
SCH 28080 is a potent inhibitor of H+,K+-ATPase that binds to the K+ recognition site and is competitive with respect to K+. Learn MoreStarting at: $139.00
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Escitalopram oxalate
Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI) (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Learn MoreStarting at: $55.00
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Fluoxetine hydrochloride
Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. It binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Learn MoreStarting at: $69.00
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Lofepramine
Lofepramine is a serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine, which produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo. Learn MoreStarting at: $90.00
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Paroxetine maleate
Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter. Learn MoreStarting at: $90.00
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WY 45233 succinate
WY 45233 succinate is a serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Learn MoreStarting at: $149.00
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Zimelidine dihydrochloride
Zimelidine dihydrochloride is a 5-HT re-uptake inhibitor that modulates nociception and induces hyperglycemia in vivo. Learn MoreStarting at: $45.00
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Dexfenfluramine hydrochloride
Dexfenfluramine hydrochloride is an indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Learn MoreStarting at: $49.00
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Citalopram hydrobromide
Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake with IC50 values of 1.8, 8800 and 41000 nM respectively. Learn MoreStarting at: $105.00
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BTS 54-505 hydrochloride
BTS 54-505 hydrochloride is a potently active primary amine metabolite of sibutramine. Learn MoreStarting at: $95.00