Kinases

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  • U0124

    U0124 is the inactive analog of U0126 which be used as a negative control. Learn More

    Starting at: $99.00

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  • U0126

    U0126 is a Potent and selective non-competitive inhibitor of MAP kinase kinase, which inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Learn More

    Starting at: $135.00

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  • PD 198306

    PD 198306 is a potent inhibitor of MEK1/2, which inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Learn More

    Starting at: $189.00

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  • PD 334581

    PD 334581, an analog of PD 184352, is an inhibitor of MEK1. Learn More

    Starting at: $198.00

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  • 10Z-Hymenialdisine

    10Z-Hymenialdisine is a pan kinase inhibitor that inhibits NF-κB activation and blocks IL-8 production in U937 cells with IC50 values of 1-2 and 0.34-0.48 μM respectively. Learn More

    Starting at: $259.00

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  • Anisomycin

    Anisomycin is a protein synthesis inhibitor (blocks translation), which acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD). Learn More

    Starting at: $65.00

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  • SU 3327

    SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM), which inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Learn More

    Starting at: $115.00

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  • AEG 3482

    AEG 3482 is an inhibitor of c-jun N-terminal kinase (JNK) signaling that binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Learn More

    Starting at: $89.00

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  • TCS JNK 6o

    TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor that inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro. Learn More

    Starting at: $149.00

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  • PF 04691502

    PF 04691502 is an potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, γ, β, and mTOR, respectively). Learn More

    Starting at: $145.00

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  • LY 303511

    LY 303511 is a negative control compound with respect to LY 294002 PI 3-kinase inhibitory activity which blocks voltage-gated potassium (Kv) channels (IC50 = 64.6 μM) and inhibits IL-1β-stimulated NF-κB activation, attenuating MCP-1 expression. Antiproliferative. Learn More

    Starting at: $75.00

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  • PI 828

    PI 828 is a PI 3-Kinase inhibitor with IC50 values of 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively. Learn More

    Starting at: $69.00

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  • SX 011

    SX 011 is a potent p38α inhibitor (IC50 = 9 nM), which also inhibits p38β and JNK-2 (IC50 values are 90 nM and 100 nM respectively). Learn More

    Starting at: $139.00

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  • EO 1428

    EO 1428 is a selective inhibitor of p38α and p38β2 that displays no activity at p38γ, p38δ, ERK1/2 and JNK1, which iInhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC50 values are 4, 5, 17, 30 and 74 nM respectively). Learn More

    Starting at: $139.00

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  • JX 401

    JX 401 is a potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively), which inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture. Learn More

    Starting at: $139.00

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  • CMPD-1

    CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of the two other known p38 substrates, MBP and ATF-2. Learn More

    Starting at: $119.00

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  • SKF 86002 dihydrochloride

    SKF 86002 dihydrochloride is an inhibitor of p38 MAP kinase that potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM) and also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells. Learn More

    Starting at: $149.00

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  • AMG 548

    AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis. Learn More

    Starting at: $189.00

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  • TC ASK 10

    TC ASK 10 is a potent ASK1 inhibitor (IC50 = 14 nM) Learn More

    Starting at: $159.00

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  • PF 3644022

    PF 3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM) which inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM). Learn More

    Starting at: $180.00

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