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Kinases
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Bisindolylmaleimide II
Bisindolylmaleimide II is a potent, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 0.01 μM) which displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC50 values are 0.75 and 2μM for PK and PKA respectively). Learn MoreStarting at: $135.00
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CGP 53353
CGP 53353 is a selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively), which inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro. Learn MoreStarting at: $155.00
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Ro 32-0432 hydrochloride
Ro 32-0432 hydrochloride is a selective cell-permeable protein kinase C inhibitor, which displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Learn MoreStarting at: $140.00
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TCS 2312
TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor that enhances the cell killing activity of Gemcitabine in breast and prostate cancer cell lines and displays antiproliferative effects in vitro. Learn MoreStarting at: $139.00
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NSC 109555 ditosylate
NSC 109555 ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor that displays no effect on a range of other kinases including Chk1. Learn MoreStarting at: $119.00
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PD 407824
PD 407824 is a selective inhibitor of checkpoint kinases Chk1 and Wee1 with IC50 values of 47 and 97 nM respectively. Learn MoreStarting at: $79.00
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SB 218078
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Learn MoreStarting at: $85.00
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DIM
DIM is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines, which inhibits phosphorylation of EGFR and downstream activation of ERK. Learn MoreStarting at: $39.00
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PPY A
PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases that inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene. Learn MoreStarting at: $169.00
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PD 180970
PD 180970 is a ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells, and inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Learn MoreStarting at: $155.00
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Adaphostin
Adaphostin is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM), which induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro and displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro. Learn MoreStarting at: $98.00
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ABT 702 dihydrochloride
ABT 702 dihydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Learn MoreStarting at: $180.00
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FPA 124
FPA 124 is an Akt/PKB inhibitor that inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo. Learn MoreStarting at: $125.00
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SC 66
SC 66 is an allosteric inhibitor of Akt that interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Learn MoreStarting at: $75.00
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PIT 1
PIT 1, a selective PIP3 antagonist, blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03;M) and also inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Learn MoreStarting at: $119.00
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API-1
API-1 is an Akt/protein kinase B (PKB) inhibitor, which binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation, and inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Learn MoreStarting at: $229.00
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SC 79
SC 79 is an activator of Akt which binds to the pleckstrin homology domain of Akt, and enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Learn MoreStarting at: $119.00
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10-DEBC hydrochloride
10-DEBC hydrochloride is a selective inhibitor of Akt/PKB, which inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Learn MoreStarting at: $90.00
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PT 1
PT 1 is an AMP-activated protein kinase (AMPK) activator, which stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Learn MoreStarting at: $139.00
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KU 60019
KU 60019 is a potent ATM kinase inhibitor with an IC50 value of 6.3 nM. Learn MoreStarting at: $189.00
