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p38 MAPK
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SX 011
SX 011 is a potent p38α inhibitor (IC50 = 9 nM), which also inhibits p38β and JNK-2 (IC50 values are 90 nM and 100 nM respectively). Learn MoreStarting at: $139.00
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EO 1428
EO 1428 is a selective inhibitor of p38α and p38β2 that displays no activity at p38γ, p38δ, ERK1/2 and JNK1, which iInhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC50 values are 4, 5, 17, 30 and 74 nM respectively). Learn MoreStarting at: $139.00
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JX 401
JX 401 is a potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively), which inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture. Learn MoreStarting at: $139.00
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CMPD-1
CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of the two other known p38 substrates, MBP and ATF-2. Learn MoreStarting at: $119.00
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SKF 86002 dihydrochloride
SKF 86002 dihydrochloride is an inhibitor of p38 MAP kinase that potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM) and also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells. Learn MoreStarting at: $149.00
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AMG 548
AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis. Learn MoreStarting at: $189.00
