Kinases
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Cercosporamide
Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Learn MoreStarting at: $115.00
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HI TOPK 032
HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor, which exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM). Learn MoreStarting at: $159.00
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XRP44X
XRP44X is a Ras-Net (Elk-3) pathway inhibitor that indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Learn MoreStarting at: $139.00
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FAK Inhibitor 14
FAK Inhibitor 14 is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Learn MoreStarting at: $95.00
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Y 11
Y 11 is a potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay) and blocks colony formation in SW620 and BT474 cell lines. Learn MoreStarting at: $99.00
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Chelerythrine chloride
Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Learn MoreStarting at: $95.00
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Phorbol 12,13-dibutyrate
Phorbol 12,13-dibutyrate is a protein kinase C activator, which induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Learn MoreStarting at: $55.00
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Phorbol 12-myristate 13-acetate
Naltrexone hydrochloride is an opioid antagonist. Learn MoreStarting at: $50.00
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LY 333531 hydrochloride
Ras CAAX peptidomimetic, a selective inhibitor of farnesyltransferase (FTase) that displays > 100-fold selectivity over geranylgeranyltransferase I (GGTase I) (IC50 values are 0.5 and 50 nM respectively). Learn MoreStarting at: $110.00
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(±)-Palmitoylcarnitine chloride
(±)-Palmitoylcarnitine chloride has a wide range of biological actions including the inhibition of protein kinase C and cell membrane disruption. Learn MoreStarting at: $89.00
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Oncrasin 1
Oncrasin 1 is a proapoptotic agent that exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Learn MoreStarting at: $105.00
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C-1
C-1 is an inhibitor of protein kinase C. Learn MoreStarting at: $105.00
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K-252c
K-252c is an inhibitor of protein kinase C that exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV). Learn MoreStarting at: $99.00
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Dihydrosphingosine
Dihydrosphingosine is a protein kinase C inhibitor. Learn MoreStarting at: $99.00
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FR 236924
FR 236924 is a selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Learn MoreStarting at: $119.00
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Rottlerin
Rottlerin is riginally reported to inhibit PKC isoforms, inhibit CAM kinase III, and inhibit a wide range of protein kinases. Learn MoreStarting at: $69.00
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SC-9
SC-9 is a potent activator of protein kinase C. Learn MoreStarting at: $95.00
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SC-10
SC-10 is a activator of protein kinase C. Learn MoreStarting at: $95.00
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Calphostin C
Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Learn MoreStarting at: $165.00
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D-erythro-Sphingosine (synthetic)
D-erythro-Sphingosine (synthetic) is an inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C. Learn MoreStarting at: $65.00