Kinases

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  • Cercosporamide

    Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3 (IC50 values are 11, 31 and 116 nM for Mnk2, JAK3 and Mnk1 respectively). Learn More

    Starting at: $115.00

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  • HI TOPK 032

    HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor, which exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM). Learn More

    Starting at: $159.00

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  • XRP44X

    XRP44X is a Ras-Net (Elk-3) pathway inhibitor that indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Learn More

    Starting at: $139.00

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  • FAK Inhibitor 14

    FAK Inhibitor 14 is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Learn More

    Starting at: $95.00

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  • Y 11

    Y 11 is a potent inhibitor of focal adhesion kinase (FAK); prevents FAK autophosphorylation at the Y397 site (IC50 ~ 50 nM in an in vitro kinase assay) and blocks colony formation in SW620 and BT474 cell lines. Learn More

    Starting at: $99.00

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  • Chelerythrine chloride

    Chelerythrine chloride is a cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Learn More

    Starting at: $95.00

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  • Phorbol 12,13-dibutyrate

    Phorbol 12,13-dibutyrate is a protein kinase C activator, which induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Learn More

    Starting at: $55.00

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  • Phorbol 12-myristate 13-acetate

    Naltrexone hydrochloride is an opioid antagonist. Learn More

    Starting at: $50.00

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  • LY 333531 hydrochloride

    Ras CAAX peptidomimetic, a selective inhibitor of farnesyltransferase (FTase) that displays > 100-fold selectivity over geranylgeranyltransferase I (GGTase I) (IC50 values are 0.5 and 50 nM respectively). Learn More

    Starting at: $110.00

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  • (±)-Palmitoylcarnitine chloride

    (±)-Palmitoylcarnitine chloride has a wide range of biological actions including the inhibition of protein kinase C and cell membrane disruption. Learn More

    Starting at: $89.00

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  • Oncrasin 1

    Oncrasin 1 is a proapoptotic agent that exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Learn More

    Starting at: $105.00

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  • C-1

    C-1 is an inhibitor of protein kinase C. Learn More

    Starting at: $105.00

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  • K-252c

    K-252c is an inhibitor of protein kinase C that exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV). Learn More

    Starting at: $99.00

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  • Dihydrosphingosine

    Dihydrosphingosine is a protein kinase C inhibitor. Learn More

    Starting at: $99.00

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  • FR 236924

    FR 236924 is a selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Learn More

    Starting at: $119.00

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  • Rottlerin

    Rottlerin is riginally reported to inhibit PKC isoforms, inhibit CAM kinase III, and inhibit a wide range of protein kinases. Learn More

    Starting at: $69.00

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  • SC-9

    SC-9 is a potent activator of protein kinase C. Learn More

    Starting at: $95.00

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  • SC-10

    SC-10 is a activator of protein kinase C. Learn More

    Starting at: $95.00

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  • Calphostin C

    Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Learn More

    Starting at: $165.00

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  • D-erythro-Sphingosine (synthetic)

    D-erythro-Sphingosine (synthetic) is an inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C. Learn More

    Starting at: $65.00

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