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7-TM Receptors
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LY 393558
LY 393558 is a dual 5-HT1B/1D receptor antagonist (pKB values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC50 = 8.48). Learn MoreStarting at: $139.00
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SB 243213 dihydrochloride
SB 243213 dihydrochloride is a selective 5-HT2C inverse agonist (pKb = 9.8), which displays selectivity over other 5-HT2 subtypes (pKi values are 6.8, 7.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C respectively). Learn MoreStarting at: $140.00
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SN 003
SN 003 is a reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Learn MoreStarting at: $140.00
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SB 221284
SB 221284 is a potent, selective 5-HT2C/2B receptor antagonist. pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively. Learn MoreStarting at: $110.00
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L-168,049
L-168,049 is a very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Learn MoreStarting at: $105.00
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L 760735
L 760735 is a high affinity NK1 receptor antagonist (IC50 = 0.19 nM at human NK1 receptors), which is selective (>300-fold) over h-NK2 and h-NK3 receptors and exhibits anxiolytic and antidepressant-like effects. Learn MoreStarting at: $145.00
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EMD 66684
EMD 66684 is a highly potent and very selective non-peptide angiotensin AT1 receptor antagonist (IC50 values are 0.7 and > 10000 nM for AT1 and AT2 receptors respectively), which potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC50 = 0.2 nM) and reduces blood pressure in hypertensive rats. Learn MoreStarting at: $135.00
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RS 102221 hydrochloride
RS 102221 hydrochloride is a potent and selective 5-HT2C antagonist (pKi = 8.7) which displays ~ 100-fold selectivity over the 5-HT2A and 5-HT2B subtypes and is > 100-fold selective over other 5-HT receptors, α- and β-adrenergic and muscarinic ACh receptors. Learn MoreStarting at: $110.00
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5-Nonyloxytryptamine oxalate
GR 159897 is a potent, selective, non-peptide, orally active neurokinin NK2 receptor antagonist , which inhibits NK2 receptor-mediated contraction of guinea pig trachea with a pA2 of 8.7. Learn MoreStarting at: $105.00
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SB 206553 hydrochloride
L-745,870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and > 1000-fold selectivity over 5-HT2, D1 and D5 receptors. Learn MoreStarting at: $145.00
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Eltoprazine hydrochloride
Eltoprazine hydrochloride is a 5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively), which reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. Learn MoreStarting at: $99.00
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WAY 161503 hydrochloride
WAY 161503 hydrochloride is a potent and selective 5-HT2C receptor agonist with antidepressant effect following systemic administration in vivo. Learn MoreStarting at: $99.00
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MK 212 hydrochloride
MK 212 hydrochloride is a 5-HT receptor agonist with selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively). Learn MoreStarting at: $92.00
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NBI 35965 hydrochloride
NBI 35965 hydrochloride is a potent and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist that inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro and attenuates CRF and ACTH production in vivo. Learn MoreStarting at: $158.00
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WAY 629 hydrochloride
WAY 629 hydrochloride is a selective 5-HT2C agonist with Ki values of 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Learn MoreStarting at: $109.00
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Isamoltane hemifumarate
Isamoltane hemifumarate is a 5-HT1B antagonist, approximately 30-fold selective over 5-HT1A. Learn MoreStarting at: $89.00
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SB 216641 hydrochloride
CD 2665 is a selective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Learn MoreStarting at: $145.00
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Ro 60-0175 fumarate
Dibutyryl-cAMP, sodium salt is a cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Learn MoreStarting at: $105.00
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CI 1020
Flunitrazepam is a ligand at the GABAA receptor benzodiazepine modulatory site which exhibits hypnotic effects and also displays anxiolytic and sedative properties. Learn MoreStarting at: $65.00
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PNU 22394 hydrochloride
MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter. Learn MoreStarting at: $95.00
