7-TM Receptors
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Tocrifluor T1117
Tocrifluor T1117 is a novel fluorescent form of AM 251, which conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543nm excitation (590nm emission), and displays GPR55 binding activity. Learn MoreStarting at: $200.00
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VU 0255035
VU 0255035 is a highly selective muscarinic M1 antagonist (Ki = 14.87 nM), which targets the M1 orthosteric site and reduces pilocarpine-induced seizures in mice. Learn MoreStarting at: $110.00
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CY 208-243
CY 208-243 is a centrally active dopamine D1 receptor agonist, selective over D2 receptor sites, which stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM, that exerts antiParkinsonian activity in animal models. Learn MoreStarting at: $139.00
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DPCPX
DPCPX is a potent and selective A1 adenosine receptor antagonist, both in vitro and in vivo. Learn MoreStarting at: $119.00
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Z-Cyclopentyl-AP4
Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist that exhibits higher potency at mGlu4 than mGlu8 (EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. And selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Learn MoreStarting at: $129.00
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(±)-5'-Chloro-5'-deoxy-ENBA
(±)-5'-Chloro-5'-deoxy-ENBA is a highly selective adenosine A1 receptor agonist (Ki values are 0.51, 1290, 1340 and 2740 nM at A1, A3, A2A and A2B receptors respectively). Learn MoreStarting at: $135.00
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SKF 77434 hydrobromide
SKF 77434 hydrobromide is a selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Learn MoreStarting at: $79.00
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Cevimeline hydrochloride
Cevimeline hydrochloride is a selective M1 receptor agonist which induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Learn MoreStarting at: $95.00
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VU 0155041
VU 0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Learn MoreStarting at: $120.00
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Naltrindole hydrochloride
Naltrindole hydrochloride is a highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ and κ opioid receptors. Learn MoreStarting at: $95.00
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Naltriben mesylate
Naltriben mesylate is a selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively), which displays selectivity for the δ2 subtype in vivo. Learn MoreStarting at: $100.00
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VU 0357017 hydrochloride
VU 0357017 hydrochloride is a positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM), which displays no activity at M2-M5 at concentrations up to 30 μM. Learn MoreStarting at: $110.00
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A 68930 hydrochloride
A 68930 hydrochloride is a potent and selective D1-like dopamine receptor agonist (EC50 values are 2.1 and 3910 nM for D1-like and D2-like receptors respectively). Learn MoreStarting at: $115.00
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SDZ WAG 994
SDZ WAG 994 is a potent and selective A1 adenosine receptor agonist (Ki values are 23, > 10000 and 25000 nM for A1, A2A and A2B receptors respectively). Learn MoreStarting at: $145.00
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SNC 162
SNC 162 is a potent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM) which displays > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo. Learn MoreStarting at: $160.00
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CPPG
CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). Learn MoreStarting at: $115.00
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ACPT-I
ACPT-I is an agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Learn MoreStarting at: $140.00
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HTMT dimaleate
HTMT dimaleate is a H1 and H2 receptor agonist, which increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3. And 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Learn MoreStarting at: $98.00
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NADA
NADA is a potent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB1 over CB2 receptors (Ki values are 0.25 and 12 μM respectively), and potent agonist at TRPV1 (VR1) receptors (EC50 ~ 50 nM). Learn MoreStarting at: $79.00
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(S)-3,4-DCPG
(S)-3,4-DCPG is a potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7, which increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Learn MoreStarting at: $140.00