Glutamate (Metabotropic) Group I Receptors

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  • VU 1545

    VU 1545 is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator. Learn More

    Starting at: $115.00

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  • CHPG

    E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG. Learn More

    Starting at: $80.00

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  • AIDA

    RS 67333 hydrochloride is a potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Learn More

    Starting at: $115.00

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  • S-Sulfo-L-cysteine sodium salt

    LY 311727 is a selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 values are <1 μM for group IIA and <50 μM for group V). Learn More

    Starting at: $140.00

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  • (S)-3,5-DHPG

    BYK 49187 is a PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively) which displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro. Learn More

    Starting at: $95.00

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  • YM 230888

    YM 230888 is a selective mGlu1 antagonist (Ki = 13 nM), which inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells (IC50 = 13 nM). Learn More

    Starting at: $135.00

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  • JNJ 16259685

    JNJ 16259685 is a sub-nanomolar potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM), which inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. Learn More

    Starting at: $169.00

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  • DMeOB

    DMeOB is a negative allosteric modulator of the metabotropic glutamate receptor mGlu5 which displays reversible non-competitive inhibition of mGlu5-mediated responses (IC50 = 3 μM). Learn More

    Starting at: $79.00

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  • ACDPP hydrochloride

    ACDPP hydrochloride is an intagonist at the mGlu5 receptor (Ki = 295 nM), which inhibits human mGlu5 receptor-mediated calcium flux with an IC50 of 134 nM. Learn More

    Starting at: $99.00

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  • LY 456236 hydrochloride

    LY 456236 hydrochloride is a selective mGlu1 receptor antagonist (IC50 values are 143 nM and > 10 μM for mGlu1 and mGlu5 receptors respectively), which reduces hyperalgesic behavior induced by formalin in both mouse and rat with ED50 values of 28 and 16.3 mg/kg respectively. Learn More

    Starting at: $89.00

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  • (S)-HexylHIBO

    (S)-HexylHIBO is a group I mGlu receptor antagonist (Kb values are 30 and 61 μM at mGlu1a and mGlu5a receptors respectively). Learn More

    Starting at: $139.00

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  • E4CPG

    (RS)-APICA is a rigidified analog of MPPG; selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Learn More

    Starting at: $95.00

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  • 3-MATIDA

    3-MATIDA is a potent metabotropic glutamate mGlu1 receptor antagonist with IC50 = 6.3 μM at rat mGlu1a. Learn More

    Starting at: $140.00

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  • (S)-3-Carboxy-4-hydroxyphenylglycine

    (S)-3-Carboxy-4-hydroxyphenylglycine is a mixed group I metabotropic glutamate receptor antagonist and group II mGlu agonist. Learn More

    Starting at: $269.00

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  • VU 29

    VU 29 is a potent allosteric potentiator at the rat mGlu5 receptor. Learn More

    Starting at: $139.00

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  • (S)-4-Carboxy-3-hydroxyphenylglycine

    (S)-4-Carboxy-3-hydroxyphenylglycine is a competitive antagonist at group I mGlu1a/1a receptors, mixed effect at mGlu5a/5b receptors. Learn More

    Starting at: $265.00

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  • CDPPB

    CDPPB is a brain penetrant, selective positive allosteric modulator at the mGlu5 receptor with reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats. Learn More

    Starting at: $119.00

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  • ADX 10059 hydrochloride

    ADX 10059 hydrochloride, analog of MPEP, is a negative allosteric modulator at the mGlu5 receptor. . Learn More

    Starting at: $139.00

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  • YM 298198 hydrochloride

    YM 298198 hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors with a Ki value of 19 nM. Learn More

    Starting at: $149.00

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  • (S)-3-Hydroxyphenylglycine

    (S)-3-Hydroxyphenylglycine is an agonist at group I metabotropic glutamate receptors (mGlu1) having no effect at mGlu2 or mGlu4. Learn More

    Starting at: $169.00

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