Protease-Activated Receptors

Q94 hydrochloride

Q94 hydrochloride is a PAR1 negative allosteric modulator (IC50 = 916 nM); which inhibits PAR1-Gαq interaction. Learn More

Starting at: $85.00

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FR 171113

FR 171113 is a protease-activated receptor 1 (PAR1) antagonist which exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM). Learn More

Starting at: $140.00

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RWJ 56110

RWJ 56110 is a selective protease-activated receptor-1 (PAR1) antagonist which displays no activity at PAR2, PAR3, or PAR4 subtypes and blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Learn More

Starting at: $119.00

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Gabexate mesylate

Gabexate mesylate is a serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively).Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Learn More

Starting at: $99.00

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AC 55541

AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist that stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro and exhibits pronociceptive activity in vivo. Learn More

Starting at: $149.00

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