Histamine H4 Receptors

VUF 8430 dihydrobromide

VUF 8430 dihydrobromide is a high affinity (pKi = 7.5), potent histamine H4 receptor full agonist (pEC50 = 7.3). Displays moderate affinity for H3 receptors (pKi = 6.0) and weak partial agonist activity at H2 receptors. Learn More

Starting at: $109.00

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VUF 10460

VUF 10460 is a selective histamine H4 receptor agonist which displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22). Learn More

Starting at: $129.00

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A 987306

A 987306 is a potent histamine H4 receptor antagonist (pKi values are 8.24 and 8.47 in human and rat H4 receptors respectively), which blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED50 = 42 μmol/kg, ip). Learn More

Starting at: $140.00

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4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes. Learn More

Starting at: $139.00

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JNJ 10191584 maleate

JNJ 10191584 maleate is a highly selective histamine H4 receptor silent antagonist that inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Learn More

Starting at: $99.00

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