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5-HT1 Receptors
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CGS 12066B dimaleate
CGS 12066B dimaleate is a 5-HT1B full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Learn MoreStarting at: $60.00
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Anpirtoline hydrochloride
Anpirtoline hydrochloride is a highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively), which decreases central serotonin synthesis and attenuates aggressive behavior in vivo. It also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant. Learn MoreStarting at: $119.00
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Eltoprazine hydrochloride
Eltoprazine hydrochloride is a 5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively), which reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. Learn MoreStarting at: $99.00
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Isamoltane hemifumarate
Isamoltane hemifumarate is a 5-HT1B antagonist, approximately 30-fold selective over 5-HT1A. Learn MoreStarting at: $89.00
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SB 216641 hydrochloride
CD 2665 is a selective RARβγ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). Learn MoreStarting at: $145.00
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5-Nonyloxytryptamine oxalate
GR 159897 is a potent, selective, non-peptide, orally active neurokinin NK2 receptor antagonist , which inhibits NK2 receptor-mediated contraction of guinea pig trachea with a pA2 of 8.7. Learn MoreStarting at: $105.00
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LY 393558
LY 393558 is a dual 5-HT1B/1D receptor antagonist (pKB values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC50 = 8.48). Learn MoreStarting at: $139.00
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NAS-181
NAS-181 is a potent, selective antagonist at the rat 5-HT1B receptor (Ki = 47 nM). Learn MoreStarting at: $155.00
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SB 224289 hydrochloride
SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2) which displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Learn MoreStarting at: $135.00
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GR 55562 dihydrochloride
GR 55562 dihydrochloride is a selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes. Learn MoreStarting at: $120.00
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Donitriptan hydrochloride
Donitriptan hydrochloride is a brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively) which inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Learn MoreStarting at: $105.00
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CP 94253 hydrochloride
CP 94253 hydrochloride is a potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Learn MoreStarting at: $140.00
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CP 93129 dihydrochloride
CP 93129 dihydrochloride is a potent and highly selective 5-HT1B agonist. Learn MoreStarting at: $105.00
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WAY 100635 maleate
WAY 100635 maleate is a potent, silent antagonist of 5-HT1A receptors with 100-fold selectivity for 5-HT1A over other 5-HT subtypes. It also has agonist activity at dopamine D4 receptors. Learn MoreStarting at: $119.00
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8-Hydroxy-DPAT hydrobromide
8-Hydroxy-DPAT hydrobromide is a standard selective 5-HT1A agonist that reduces hippocampal 5-HT levels following systemic administration in rats in vivo. Learn MoreStarting at: $59.00
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(R)-(+)-8-Hydroxy-DPAT hydrobromide
(R)-(+)-8-Hydroxy-DPAT hydrobromide is a full 5-HT1A serotonin receptor agonist that reduces hippocampal 5-HT levels following systemic administration in rats in vivo. It is more active enantiomer of 8-Hydroxy-DPAT hydrobromide. Learn MoreStarting at: $109.00
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BP 554 maleate
BP 554 maleate is a selective 5-HT1A agonist. Learn MoreStarting at: $95.00
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Xaliproden hydrochloride
Xaliproden hydrochloride is an orally active, full agonist at 5-HT1A receptors that is > 300-fold selective over other 5-HT receptor subtypes with an IC50 value of > 650 nM. Learn MoreStarting at: $105.00
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Ipsapirone
Ipsapirone is a selective 5-HT1A receptor agonist with a Ki value of 10 nM. Learn MoreStarting at: $99.00
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8-Hydroxy-PIPAT oxalate
SCH 58261 is a potent and selective A2A adenosine receptor competitive antagonist (Ki = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively. Learn MoreStarting at: $120.00
