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7-TM Receptors
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Anpirtoline hydrochloride
Anpirtoline hydrochloride is a highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively), which decreases central serotonin synthesis and attenuates aggressive behavior in vivo. It also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant. Learn MoreStarting at: $119.00
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NBI 27914 hydrochloride
NBI 27914 hydrochloride is a selective, non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonist (Ki = 1.7 nM) which blocks behavioral seizures in vivo. Learn MoreStarting at: $110.00
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SB 242084
SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. Learn MoreStarting at: $140.00
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FR 139317
FR 139317 is a highly potent and selective ETA endothelin receptor antagonist (Ki values are 1 nM and 7.3 μM at ETA and ETB subtypes respectively). Learn MoreStarting at: $155.00
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FK 888
FK 888 is a selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors which inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration. Learn MoreStarting at: $195.00
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CP 99994 dihydrochloride
CP 99994 dihydrochloride is a high affinity NK1 antagonist (Ki = 0.145 nM in vitro) which displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Learn MoreStarting at: $150.00
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SR 27897
SR 27897 is a potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Learn MoreStarting at: $135.00
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RP 67580
RP 67580 is a potent and selective tachykinin NK1 receptor antagonist (Ki values are 2.9 nM and > 10 μM for rat NK1, and rat NK2 and NK3 receptors respectively), which displays higher affinity at rat and mouse than human receptors. Learn MoreStarting at: $135.00
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CP 96345
CP 96345 is a potent and selective non-peptide NK1 receptor antagonist. Learn MoreStarting at: $135.00
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CP 94253 hydrochloride
CP 94253 hydrochloride is a potent, selective 5-HT1B agonist (Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively). Learn MoreStarting at: $140.00
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CP 93129 dihydrochloride
CP 93129 dihydrochloride is a potent and highly selective 5-HT1B agonist. Learn MoreStarting at: $105.00
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CGS 12066B dimaleate
CGS 12066B dimaleate is a 5-HT1B full agonist, 10-fold selective over 5-HT1A and 1000-fold selective over 5-HT2C receptors. Learn MoreStarting at: $60.00
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Devazepide
Devazepide is a potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Devazepide blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration. Learn MoreStarting at: $149.00
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SB 200646 hydrochloride
SB 200646 hydrochloride is a 5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Learn MoreStarting at: $135.00
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1-Methylpsilocin
1-Methylpsilocin is a potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively) which displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Learn MoreStarting at: $95.00
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ZD 7155 hydrochloride
ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Learn MoreStarting at: $115.00
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SB 228357
SB 228357 is a 5-HT2C/2B receptor antagonist (pKi values are 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors respectively) which displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Learn MoreStarting at: $140.00
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SB 224289 hydrochloride
SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2) which displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Learn MoreStarting at: $135.00
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SDZ NKT 343
SDZ NKT 343 is a highly selective human tachykinin NK1 receptor antagonist (IC50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK2 and NK3 receptors. Learn MoreStarting at: $195.00
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CP 376395 hydrochloride
CP 376395 hydrochloride is a potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively). Learn MoreStarting at: $135.00
