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7-TM Receptors
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(±)-Clopidogrel hydrochloride
(±)-Clopidogrel hydrochloride is a selective, high affinity P2Y12 receptor antagonist that inhibits ADP-induced platelet aggregation. Learn MoreStarting at: $99.00
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MRS 2500 tetraammonium salt
MRS 2500 tetraammonium salt is a highly potent and selective antagonist of the platelet P2Y1 receptor with a Ki value of 0.78 nM. Learn MoreStarting at: $239.00
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PIT
PIT is a Purinergic P2Y receptor ligand that Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y1 receptor and sympathetic/purinergic nerve stimulation). Learn MoreStarting at: $95.00
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Ticlopidine hydrochloride
Ticlopidine hydrochloride, a selective P2Y12 receptor antagonist, inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo. Learn MoreStarting at: $38.00
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MRS 2365
MRS 2365 is a highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM), which displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 μM). Increases the upregulation of NTPDase1 by ATPγS. Learn MoreStarting at: $249.00
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MRS 2279
MRS 2279 is a selective, high affinity competitive antagonist of the P2Y1 receptor (Ki = 2.5 nM; IC50 = 51.6 nM). Learn MoreStarting at: $259.00
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3,5-DHBA
3,5-DHBA is a selective agonist of hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) (EC50 ~150 μM), Inhibits lipolysis in wild-type mouse adipocytes. Learn MoreStarting at: $59.00
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TUG 891
TUG 891 is a potent GPR120 agonist (pEC50 values are 7.36 and 7.77 for human and mouse GPR120 respectively). Learn MoreStarting at: $120.00
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TC-O 9311
TC-O 9311 is a potent GPR139 agonist (EC50 = 39 nM in CHO-K1 cells expressing human GPR139), which displays no activity against a range of 90 diverse targets. Learn MoreStarting at: $119.00
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Grifolic acid
Grifolic acid is a selective partial GPR120 agonist that induces ERK and [Ca2+]i responses in cells expressing GPR120. Learn MoreStarting at: $119.00
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PF9 tetrasodium salt
PF9 tetrasodium salt is a potent agonist of GPR17 with an EC50 value of 36 pM. Learn MoreStarting at: $195.00
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PD 160170
PD 160170 is a potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM); selective over Y2 and Y5 receptors (Ki > 10 μM). Learn MoreStarting at: $110.00
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BMS 193885
BMS 193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Learn MoreStarting at: $168.00
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BIBO 3304 trifluoroacetate
BIBO 3304 trifluoroacetate is a high affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Learn MoreStarting at: $215.00
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CGP 71683 hydrochloride
Extremely selective, non-peptide NPY Y5 receptor antagonist. Displays > 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Learn MoreStarting at: $139.00
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S 25585
S 25585 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Learn MoreStarting at: $139.00
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LU AA33810
LU AA33810 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (Ki = 1.5 nM in vitro) which displays ≥ 3300-fold affinity for Y5 over Y1, Y2 and Y4 receptors. Learn MoreStarting at: $109.00
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NPY 5RA972
NPY 5RA972 is a potent and selective neuropeptide Y Y5 receptor antagonist (IC50 values are 3.1, >10000, >10000 and >10000 nM for Y5, Y1, Y2 and Y4 receptors respectively). Does not block NPY-induced feeding in vivo. Orally active and brain penetrant. Learn MoreStarting at: $135.00
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SF 11
SF 11 is a NPY Y2 antagonist (IC50 = 199 nM), which displays no affinity for Y1 receptor at concentrations up to 35 μM. Causes significant lethality in mice. Brain penetrant. Learn MoreStarting at: $139.00
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NTNCB hydrochloride
NTNCB hydrochloride is a selective, non-peptide competitive NPY Y5 antagonist. Ki values are 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively. Learn MoreStarting at: $149.00
