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7-TM Receptors
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W146
W146 is a potent sphingosine-1-phosphate receptor S1P1 selective antagonist that enhances capillary leakage and restores lymphocyte egress in vivo. Learn MoreStarting at: $109.00
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JTE 013
JTE 013, a sphingosine-1-phosphate (S1P) receptor antagonist, inhibits S1P binding to human S1P2 receptors with an IC50 value of 17.6 nM. Learn MoreStarting at: $149.00
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VPC 23019
VPC 23019 is a sphingosine-1-phosphate receptor antagonist, which inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively). Learn MoreStarting at: $219.00
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AC 55541
AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist that stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro and exhibits pronociceptive activity in vivo. Learn MoreStarting at: $149.00
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Gabexate mesylate
Gabexate mesylate is a serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively).Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Learn MoreStarting at: $99.00
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RWJ 56110
RWJ 56110 is a selective protease-activated receptor-1 (PAR1) antagonist which displays no activity at PAR2, PAR3, or PAR4 subtypes and blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Learn MoreStarting at: $119.00
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FR 171113
FR 171113 is a protease-activated receptor 1 (PAR1) antagonist which exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM). Learn MoreStarting at: $140.00
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Q94 hydrochloride
Q94 hydrochloride is a PAR1 negative allosteric modulator (IC50 = 916 nM); which inhibits PAR1-Gαq interaction. Learn MoreStarting at: $85.00
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SMANT hydrochloride
SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism, which inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Learn MoreStarting at: $95.00
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MRT 10
MRT 10 is a smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo), which inhibits ShhN-induced Gli luciferase reporter activity in Shh-light2 cells (IC50 = 2.5 μM); acts as an inverse agonist during nontranscriptional hedgehog pathway activation (IC50 = 2.5 μM in HEK293 cells). Learn MoreStarting at: $119.00
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RuBi-GABA
RuBi-GABA is a Ruthenium-bipyridine-triphenylphosphine caged GABA that is excited by visible wavelengths, which provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Learn MoreStarting at: $145.00
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SC 19220
SC 19220 is a selective EP1 receptor antagonist (IC50 = 6.7 μM for inhibition of [3H]-PGE2 binding to EP1 transfected COS cells). Learn MoreStarting at: $129.00
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BMY 45778
BMY 45778 is a non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP1 prostacyclin receptors, which potently inhibits platelet aggregation in vitro (IC50 = 27-35 nM). Learn MoreStarting at: $135.00
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L-161,982
L-161,982 is an EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively). Learn MoreStarting at: $199.00
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SC 51089
SC 51089 is a selective EP1 prostanoid receptor antagonist (Ki values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μM for EP1, TP, EP3, EP2, EP4, FP and DP receptors respectively). Learn MoreStarting at: $115.00
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SC 51322
SC 51322 is a potent EP1 prostanoid receptor antagonist (Ki = 13.8 nM), which displays analgesic properties in vivo. Learn MoreStarting at: $105.00
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Latanoprost
Latanoprost is a FP prostaglandin receptor agonist, which exhibits agonist activity at EP1 and EP3 receptors and displays greater selectivity than prostanglandin F2α . Learn MoreStarting at: $175.00
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L-670,596
L-670,596 is a potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist (IC50 = 5.5 nM), which inhibits U-44069-induced contractions of guinea pig trachea (pA2 = 9.0) and human platelet aggregation in vitro (IC50 = 6.5 nM). Learn MoreStarting at: $135.00
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ICI 192,605
ICI 192,605 is a potent thromboxane A2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U 46619. Learn MoreStarting at: $95.00
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L-655,240
L-655,240 is a potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist. pA2 values are 8 - 8.4 in guinea pig smooth muscle; IC50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo. Learn MoreStarting at: $105.00
