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Enzymes
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L-NAME hydrochloride
L-NAME hydrochloride is a NO synthase inhibitor. Learn MoreStarting at: $49.00
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L-NMMA acetate
L-NMMA acetate is competitive, irreversible inhibitor of all three NOS isoforms. Learn MoreStarting at: $49.00
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SKF 86002 dihydrochloride
SKF 86002 dihydrochloride is an inhibitor of p38 MAP kinase that potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM) and also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells. Learn MoreStarting at: $149.00
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AMG 548
AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis. Learn MoreStarting at: $189.00
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JX 401
JX 401 is a potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively), which inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture. Learn MoreStarting at: $139.00
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EO 1428
EO 1428 is a selective inhibitor of p38α and p38β2 that displays no activity at p38γ, p38δ, ERK1/2 and JNK1, which iInhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC50 values are 4, 5, 17, 30 and 74 nM respectively). Learn MoreStarting at: $139.00
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SX 011
SX 011 is a potent p38α inhibitor (IC50 = 9 nM), which also inhibits p38β and JNK-2 (IC50 values are 90 nM and 100 nM respectively). Learn MoreStarting at: $139.00
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7-Nitroindazole
7-Nitroindazole is a reversible, competitive and non-selective NOS inhibitor. Learn MoreStarting at: $65.00
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7-NINA
7-NINA is a sodium salt of the non-selective NOS inhibitor 7-nitroindazole. Learn MoreStarting at: $69.00
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TRIM
TRIM is a potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). Learn MoreStarting at: $59.00
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L-Canavanine sulfate
L-Canavanine sulfate is a NO synthase inhibitor. Learn MoreStarting at: $79.00
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L-NNA
L-NNA is a NO synthase inhibitor. Learn MoreStarting at: $49.00
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WWL 70
WWL 70 is a potent inhibitor of α/β-hydrolase domain 6 (ABHD6) with an IC50 of 70 nM. Learn MoreStarting at: $75.00
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Moexipril hydrochloride
Moexipril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor that decreases mean blood pressure in the spontaneous hypertensive rat (SHR) and also blocks degradation of bradykinin into inactive metabolites. Learn MoreStarting at: $109.00
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Flurofamide
Flurofamide is an urease inhibitor. Learn MoreStarting at: $99.00
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Captopril
Captopril is a angiotensin-converting enzyme (ACE) inhibitor that also displays reversible, competitive inhibition of leukotriene A4 (LTA4) hydrolase. Learn MoreStarting at: $38.00
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JW 480
JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (AADACL1) (IC50 = 20 nM in mouse brain). Learn MoreStarting at: $75.00
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XRP44X
XRP44X is a Ras-Net (Elk-3) pathway inhibitor that indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Learn MoreStarting at: $139.00
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HI TOPK 032
HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor, which exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM). Learn MoreStarting at: $159.00
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L-NIO dihydrochloride
L-NIO dihydrochloride is a potent inhibitor of endothelial NO synthase (IC50 = 500 nM). Also inhibits iNOS and nNOS. Learn MoreStarting at: $59.00
