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Kinases
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KT 5823
KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively), which inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM. Learn MoreStarting at: $115.00
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Rp-8-Br-PET-cGMPS
Rp-8-Br-PET-cGMPS is a competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog. Learn MoreStarting at: $135.00
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SB 590885
SB 590885 is a potent B-Raf inhibitor (Kd = 0.3 nM), which is elective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively), and decreases anchorage-independent growth of melanoma cell lines. It also inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. Learn MoreStarting at: $159.00
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BRD 7389
BRD 7389 is a p90 ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively), which upregulates insulin expression in terminally differentiated pancreatic α-cells. Learn MoreStarting at: $139.00
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SKI II
SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Learn MoreStarting at: $99.00
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N,N-Dimethylsphingosine
N,N-Dimethylsphingosine is a competitive sphingosine kinase (SphK) inhibitor which exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells, and inhibits sphingosine phosphorylation. Learn MoreStarting at: $90.00
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SK1-I
SK1-I is a sphingosine kinase (SphK) inhibitor which inhibits the growth of both U937 and Jurkat T cells, and suppresses proliferation and induces apoptosis in several human glioblastoma cell lines. Learn MoreStarting at: $180.00
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KB SRC 4
KB SRC 4 is a potent and selective c-Src inhibitor (Ki = 44 nM) and significantly inhibits cell growth in 4T1 mammary carcinoma tumor cells. Learn MoreStarting at: $175.00
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MNS
MNS is a selective inhibitor of Src and Syk tyrosine kinases which displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). Learn MoreStarting at: $65.00
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Src I1
Src I1 is a potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively) which inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Learn MoreStarting at: $120.00
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AZM 475271
AZM 475271 is a src tyrosine kinase inhibitor, which reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Learn MoreStarting at: $179.00
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Damnacanthal
Damnacanthal is a potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation), which displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Learn MoreStarting at: $115.00
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PP 3
PP 3 is a negative control for the Src kinase inhibitor PP 2 Inhibits EGFR kinase (IC50 = 2.7 μM). Learn MoreStarting at: $139.00
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Herbimycin A
Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor that binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Learn MoreStarting at: $125.00
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ER 27319 maleate
ER 27319 maleate is a selective inhibitor of Syk kinase which inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events. Learn MoreStarting at: $98.00
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INDY
INDY is a dyrk1A/B inhibitor (IC50 values are 0.23 and 0.24 μM, for Dyrk1B and Dyrk1A respectively), which binds at the ATP-binding cleft of the enzyme. Learn MoreStarting at: $105.00
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±-AMG 487
±-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively), which inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Learn MoreStarting at: $189.00
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(Z)-FeCP-oxindole
(Z)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
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ProINDY
ProINDY is a Dyrk1A/B inhibitor that inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Learn MoreStarting at: $125.00
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TG 003
TG 003 is a potent, ATP-competitive inhibitor of Clk-family kinases that suppresses serine/arginine-rich protein phosphorylation and affects the regulation of alternative splicing by phosphorylation of SR protein both in vivo and in vitro. Learn MoreStarting at: $139.00
