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Enzymes
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Ro 3306
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn MoreStarting at: $139.00
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NU 2058
This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Learn MoreStarting at: $100.00
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NU 6140
NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor which induces cell-cycle arrest at the G2-M phase. 10- to 36-fold more selective for cdk2-cyclin A over other cdks (IC50 = 0.41 μM for cdk2-cyclin A). Learn MoreStarting at: $139.00
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NSC 693868
NSC 693868 is an inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC50 values are 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively. Learn MoreStarting at: $139.00
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Ro 20-1724
Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). Learn MoreStarting at: $59.00
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IBMX
IBMX is a phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively) which suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Learn MoreStarting at: $59.00
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ICI 63197
ICI 63197 is a potent phosphodiesterase (PDE) 4 inhibitor (IC50 = 35 nM for inhibition of [3H]-rolipram binding to rat brain). Learn MoreStarting at: $99.00
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YM 976
YM 976 is an orally active PDE4 inhibitor (IC50 = 2.2 nM). Low emetogenic activity, suggested to be due to poor brain penetration. Learn MoreStarting at: $98.00
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Mesopram
Mesopram is an orally active phosphodiesterase (PDE) 4 inhibitor which inhibits Th1 cell proliferation and decreases production of IFN-γ, TNF-α, IL-10 and iNOS in vitro. Learn MoreStarting at: $135.00
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RS 25344 hydrochloride
RS 25344 hydrochloride is a potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro. Learn MoreStarting at: $115.00
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Piclamilast
Piclamilast is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 1 nM at PDE4 from human neutrophils) which displays >19,000-fold selectivity over other PDE isoenzymes. Learn MoreStarting at: $140.00
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CP 80633
CP 80633 is a selective inhibitor of phosphodiesterase type 4 (IC50 values are 1.9, > 100, > 100, > 100 and > 100 μM for human lung PDE4, lung PDE1, lung PDE2, heart PDE3 and platelet PDE-V respectively) that displays no significant PDE4 isozyme selectivity. Learn MoreStarting at: $135.00
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Siguazodan
Siguazodan is a phosphodiesterase inhibitor, selective for PDE3 (IC50 = 117 nM). Learn MoreStarting at: $100.00
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Pentoxifylline
Pentoxifylline is a phosphodiesterase inhibitor that blocks production of TNF-&alpha and other cytokines. Learn MoreStarting at: $69.00
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T 0156 hydrochloride
T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5); more selective than sildenafil (IC50 values are 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Learn MoreStarting at: $139.00
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Gisadenafil besylate
Gisadenafil besylate is a PDE5 inhibitor. Learn MoreStarting at: $159.00
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(R)-(-)-Rolipram
(R)-(-)-Rolipram is an enantiomer of the PDE4 inhibitor rolipram that is 2-10-fold more potent than the S-(+) enantiomer. Learn MoreStarting at: $139.00
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Irsogladine maleate
Irsogladine maleate is a phosphodiesterase 4 (PDE4) inhibitor that prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Learn MoreStarting at: $99.00
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Trequinsin hydrochloride
Trequinsin hydrochloride is an extremely potent inhibitor of cGMP-inhibited phosphodiesterase that inhibits arachidonic acid-induced aggregation of human platelets. Learn MoreStarting at: $199.00
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MY-5445
MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase. Learn MoreStarting at: $89.00
