Glutamate (Metabotropic) Receptors

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  • UBP1112

    UBP1112 is a selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors). Learn More

    Starting at: $139.00

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  • MSOP

    MSOP is a selective group III metabotropic glutamate receptor antagonist that displays an apparent KDof 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Learn More

    Starting at: $138.00

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  • VU 0364770

    VU 0364770 is a positive allosteric modulator at mGlu4 receptors with EC50 of 290 nM in mGlu4-expressing HEK 293 cells that prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Learn More

    Starting at: $109.00

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  • Cinnabarinic acid

    Cinnabarinic acid is a mGlu4 receptor agonist that activates mGlu4 receptors in transiently transfected HEK293 cells, decreases cAMP levels in native cultured cerebellar granule cells and also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells. Learn More

    Starting at: $129.00

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  • O-Phospho-L-serine

    O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4, which inhibits proliferation and enhances neuronal differentiation in progenitor cells. Learn More

    Starting at: $59.00

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  • CPPG

    CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). Learn More

    Starting at: $115.00

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  • ACPT-I

    ACPT-I is an agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Learn More

    Starting at: $140.00

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  • (S)-3,4-DCPG

    (S)-3,4-DCPG is a potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7, which increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Learn More

    Starting at: $140.00

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  • MPPG

    MTPG is a group II/group III metabotropic glutamate receptor antagonist, showing selectivity for group II in electrophysiological studies. Learn More

    Starting at: $135.00

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  • L-AP4

    L-AP4 is a selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Learn More

    Starting at: $60.00

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  • MMPIP hydrochloride

    MMPIP hydrochloride is a potent allosteric mGlu7-selective receptor antagonist, which inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Learn More

    Starting at: $65.00

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  • TC-N 22A

    TC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells). Learn More

    Starting at: $135.00

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  • NPEC-caged-(S)-3,4-DCPG

    NPEC-caged-(S)-3,4-DCPG is a (S)-3,4-DCPG caged with the photosensitive 1-(2-nitrophenyl)ethoxycarbonyl group. Learn More

    Starting at: $215.00

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  • VU 0155041 sodium salt

    VU 0155041 sodium salt is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Learn More

    Starting at: $50.00

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  • VU 0155041

    VU 0155041 is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Learn More

    Starting at: $120.00

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  • (RS)-PPG

    (RS)-PPG is a potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8. Learn More

    Starting at: $100.00

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  • AMN 082 dihydrochloride

    AMN 082 dihydrochloride is the first selective mGlu7 agonist, which potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Learn More

    Starting at: $89.00

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  • Z-Cyclopentyl-AP4

    Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist that exhibits higher potency at mGlu4 than mGlu8 (EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. And selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Learn More

    Starting at: $129.00

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  • TCN 238

    TCN 238 is a positive allosteric modulator of mGlu4 receptors (EC50 = 1.0 μM for human and rat mGlu4 receptors). Learn More

    Starting at: $105.00

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  • (S)-3,5-DHPG

    BYK 49187 is a PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively) which displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro. Learn More

    Starting at: $95.00

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