mAChR

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  • Nitrocaramiphen hydrochloride

    Nitrocaramiphen hydrochloride is a muscarinic antagonist with 71-fold selectivity for M1 over M2. Learn More

    Starting at: $95.00

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  • Cevimeline hydrochloride

    Cevimeline hydrochloride is a selective M1 receptor agonist which induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Learn More

    Starting at: $95.00

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  • VU 0357017 hydrochloride

    VU 0357017 hydrochloride is a positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM), which displays no activity at M2-M5 at concentrations up to 30 μM. Learn More

    Starting at: $110.00

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  • VU 0255035

    VU 0255035 is a highly selective muscarinic M1 antagonist (Ki = 14.87 nM), which targets the M1 orthosteric site and reduces pilocarpine-induced seizures in mice. Learn More

    Starting at: $110.00

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  • McN-A 343

    McN-A 343 is a selective muscarinic M1 receptor agonist with selectivity for M1 over other muscarinic receptor types appears to arise from a high efficacy at M1 receptors. Learn More

    Starting at: $37.00

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  • Telenzepine dihydrochloride

    Telenzepine dihydrochloride is a selective high affinity muscarinic M1 receptor antagonist (Ki = 0.94 nM) which inhibits gastric acid secretion. Learn More

    Starting at: $50.00

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  • Pirenzepine dihydrochloride

    Pirenzepine dihydrochloride is a M1 muscarinic receptor selective antagonist. Learn More

    Starting at: $65.00

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  • AF-DX 116

    AF-DX 116 is a selective M2 muscarinic receptor antagonist. Ki values are 64, 417, 786, 211 and 5130 nM for human recombinant M2, M1, M3, M4 and M5 muscarinic receptors, respectively. Learn More

    Starting at: $105.00

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  • Arecaidine but-2-ynyl ester tosylate

    Arecaidine but-2-ynyl ester tosylate is a potent muscarinic agonist, 4.6-fold selective for M2 receptors in the atrium versus those in the ileum. Learn More

    Starting at: $95.00

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  • Arecaidine propargyl ester tosylate

    Arecaidine propargyl ester tosylate is a potent muscarinic receptor agonist which shows some selectivity for cardiac versus ileal M2 receptors. Learn More

    Starting at: $70.00

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  • AF-DX 384

    AF-DX 384 is a potent M2/M4 selective antagonist (pKi values are 8.22, 8.00, 7.51, 7.18 and 6.27 at human M2, M4, M1, M3 and M5 receptors respectively). Learn More

    Starting at: $95.00

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  • AQ-RA 741

    AQ-RA 741 is a high affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). Learn More

    Starting at: $100.00

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  • (S)-(+)-Dimethindene maleate

    (S)-(+)-Dimethindene maleate is an enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Learn More

    Starting at: $135.00

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  • Zamifenacin fumarate

    Zamifenacin fumarate is a selective M3 muscarinic receptor antagonist (pKi values are 8.52, 7.93, 7.90 and 7.78 for M3, M2, M1 and M4 receptors respectively), which inhibits gastrointestinal motility in vivo in the absence of cardiovascular effects. Learn More

    Starting at: $135.00

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  • J 104129 fumarate

    J 104129 fumarate is a potent M3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490 nM for human M3, M1 and M2 receptors respectively). Learn More

    Starting at: $139.00

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  • 4-DAMP

    4-DAMP is an antagonist at the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors. Learn More

    Starting at: $90.00

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  • DAU 5884 hydrochloride

    DAU 5884 hydrochloride is a selective muscarinic M3 receptor antagonist. Learn More

    Starting at: $99.00

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  • VU 152100

    VU 152100 is a selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM), which induces 21-fold shift in ACh potency at M4 receptor. Learn More

    Starting at: $119.00

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  • VU 10010

    VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptors that binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins. Learn More

    Starting at: $129.00

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  • PD 102807

    PD 102807 is a selective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively. Learn More

    Starting at: $140.00

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