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Kinases
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Adaphostin
Adaphostin is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM), which induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro and displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro. Learn MoreStarting at: $98.00
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PD 180970
PD 180970 is a ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells, and inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Learn MoreStarting at: $155.00
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DIM
DIM is an activator of Chk2 that causes G2/M cell cycle arrest in various cancer cell lines, which inhibits phosphorylation of EGFR and downstream activation of ERK. Learn MoreStarting at: $39.00
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SB 218078
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Learn MoreStarting at: $85.00
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PD 407824
PD 407824 is a selective inhibitor of checkpoint kinases Chk1 and Wee1 with IC50 values of 47 and 97 nM respectively. Learn MoreStarting at: $79.00
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NSC 109555 ditosylate
NSC 109555 ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor that displays no effect on a range of other kinases including Chk1. Learn MoreStarting at: $119.00
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TCS 2312
TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor that enhances the cell killing activity of Gemcitabine in breast and prostate cancer cell lines and displays antiproliferative effects in vitro. Learn MoreStarting at: $139.00
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Ro 32-0432 hydrochloride
Ro 32-0432 hydrochloride is a selective cell-permeable protein kinase C inhibitor, which displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Learn MoreStarting at: $140.00
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CGP 53353
CGP 53353 is a selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively), which inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro. Learn MoreStarting at: $155.00
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Bisindolylmaleimide II
Bisindolylmaleimide II is a potent, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 0.01 μM) which displays selectivity for PKC over protein kinase A (PKA) and phosphorylase kinase (PK) (IC50 values are 0.75 and 2μM for PK and PKA respectively). Learn MoreStarting at: $135.00
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D-erythro-Sphingosine (synthetic)
D-erythro-Sphingosine (synthetic) is an inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C. Learn MoreStarting at: $65.00
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Calphostin C
Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Learn MoreStarting at: $165.00
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SC-10
SC-10 is a activator of protein kinase C. Learn MoreStarting at: $95.00
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SC-9
SC-9 is a potent activator of protein kinase C. Learn MoreStarting at: $95.00
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Rottlerin
Rottlerin is riginally reported to inhibit PKC isoforms, inhibit CAM kinase III, and inhibit a wide range of protein kinases. Learn MoreStarting at: $69.00
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FR 236924
FR 236924 is a selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Learn MoreStarting at: $119.00
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Dihydrosphingosine
Dihydrosphingosine is a protein kinase C inhibitor. Learn MoreStarting at: $99.00
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K-252c
K-252c is an inhibitor of protein kinase C that exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV). Learn MoreStarting at: $99.00
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C-1
C-1 is an inhibitor of protein kinase C. Learn MoreStarting at: $105.00
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Oncrasin 1
Oncrasin 1 is a proapoptotic agent that exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Learn MoreStarting at: $105.00
