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Kinases
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NU 6140
NU 6140 is a cyclin-dependent kinase 2 (cdk2) inhibitor which induces cell-cycle arrest at the G2-M phase. 10- to 36-fold more selective for cdk2-cyclin A over other cdks (IC50 = 0.41 μM for cdk2-cyclin A). Learn MoreStarting at: $139.00
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NU 2058
This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Learn MoreStarting at: $100.00
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Ro 3306
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn MoreStarting at: $139.00
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PHA 767491 hydrochloride
PHA 767491 hydrochloride is a potent, ATP-competitive dual cdc7/cdk9 inhibitor with IC50 valuesof 10 and 34 nM respectively. Learn MoreStarting at: $99.00
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TBB
TBB is a cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Learn MoreStarting at: $65.00
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PF 4800567 hydrochloride
PF 4800567 hydrochloride is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). Learn MoreStarting at: $125.00
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(R)-DRF053 dihydrochloride
(R)-DRF053 dihydrochloride is a potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively), which also shown to inhibit amyloid-β production in N2A-APP695 cells. Learn MoreStarting at: $140.00
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LFM-A13
LFM-A13 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK) that inhibits recombinant BTK with an IC50 value of 2.5 μM and has no activity on other protein kinases. Learn MoreStarting at: $129.00
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(-)-Terreic acid
Selective inhibitor of Bruton's tyrosine kinase (BTK), which inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Learn MoreStarting at: $155.00
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Mirin
Mirin is a mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. It also blocks homology-directed repair in vitro. Learn MoreStarting at: $95.00
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KU 60019
KU 60019 is a potent ATM kinase inhibitor with an IC50 value of 6.3 nM. Learn MoreStarting at: $189.00
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PT 1
PT 1 is an AMP-activated protein kinase (AMPK) activator, which stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Learn MoreStarting at: $139.00
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10-DEBC hydrochloride
10-DEBC hydrochloride is a selective inhibitor of Akt/PKB, which inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Learn MoreStarting at: $90.00
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SC 79
SC 79 is an activator of Akt which binds to the pleckstrin homology domain of Akt, and enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Learn MoreStarting at: $119.00
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API-1
API-1 is an Akt/protein kinase B (PKB) inhibitor, which binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation, and inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Learn MoreStarting at: $229.00
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PIT 1
PIT 1, a selective PIP3 antagonist, blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03;M) and also inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Learn MoreStarting at: $119.00
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SC 66
SC 66 is an allosteric inhibitor of Akt that interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Learn MoreStarting at: $75.00
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FPA 124
FPA 124 is an Akt/PKB inhibitor that inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo. Learn MoreStarting at: $125.00
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ABT 702 dihydrochloride
ABT 702 dihydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Learn MoreStarting at: $180.00
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PPY A
PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases that inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene. Learn MoreStarting at: $169.00
