You have no items in your shopping cart.
Kinases
-
TCS 2002
TCS 2002 is a potent inhibitor of GSK-3β (IC50 = 35 nM), that inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain. Learn MoreStarting at: $129.00
-
TC-G 24
TC-G 24 is a potent GSK-3β inhibitor (IC50 = 17 nM), which displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Learn MoreStarting at: $135.00
-
A 1070722
A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) which displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Learn MoreStarting at: $135.00
-
3F8
L-755,507 is a potent β3-adrenergic receptor partial agonist > 1000-fold selective over β1- and β2-adrenoceptors (EC50 values are 0.43, 580 and > 10000 nM for activation of cloned human β3-, β1- and β2-adrenoceptors respectively). Learn MoreStarting at: $115.00
-
Indirubin-3'-oxime
ARL 67156 trisodium salt is a selective ecto-ATPase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively). Learn MoreStarting at: $110.00
-
BIO
BIO is a potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor that maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro and also promotes proliferation and dedifferentiation in cardiomyocytes. Learn MoreStarting at: $109.00
-
BIO-acetoxime
BIO-acetoxime is a selective GSK-3α/β inhibitor that induces Wnt signaling and inhibits CD8+ T cell effector differentiation. Learn MoreStarting at: $89.00
-
MeBIO
MeBIO is an Aryl hydrocarbon receptor (AhR) agonist that causes redistribution of AhR to the nucleus. Learn MoreStarting at: $119.00
-
PF 04885614
PF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel), which exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Learn MoreStarting at: $125.00
-
KU 0060648
KU 0060648 is a dual, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and PI 3-K. Learn MoreStarting at: $195.00
-
DMNB
DMNB is an inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 15 μM), an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair in human cells. Learn MoreStarting at: $45.00
-
Dioctanoylglycol
Dioctanoylglycol is a specific inhibitor of diacylglycerol kinase. Learn MoreStarting at: $109.00
-
Olomoucine
Olomoucine is a cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase and selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM) and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase. Learn MoreStarting at: $99.00
-
Arcyriaflavin A
Arcyriaflavin A is a potent inhibitor of cdk4/cyclin D1 (IC50 = 59 nM), which inhibits human cytomegalovirus (HCMV) replication in vitro (IC50 = 200 nM). Learn MoreStarting at: $135.00
-
NSC 625987
NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 0.2 μM at cdk4/cyclin D1) which displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E). Learn MoreStarting at: $115.00
-
Purvalanol A
Purvalanol A is a cyclin-dependent kinase inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Learn MoreStarting at: $140.00
-
Aminopurvalanol A
Aminopurvalanol A is a cell-permeable cyclin-dependent kinase inhibitor. Learn MoreStarting at: $140.00
-
Ryuvidine
Ryuvidine is a cyclin-dependent kinase (cdk) 4 inhibitor (IC50 = 6.0 μM at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC50 > 200 μM at cdk2/cyclin A). Learn MoreStarting at: $139.00
-
(R)-CR8
(R)-CR8 is an inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 0.13 μM for cdk1/cyclin B and cdk5/p25; and 0.6 μM for CK1). Learn MoreStarting at: $159.00
-
NSC 693868
NSC 693868 is an inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC50 values are 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively. Learn MoreStarting at: $139.00
