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Kinases
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Damnacanthal
Damnacanthal is a potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation), which displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Learn MoreStarting at: $115.00
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PP 3
PP 3 is a negative control for the Src kinase inhibitor PP 2 Inhibits EGFR kinase (IC50 = 2.7 μM). Learn MoreStarting at: $139.00
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Herbimycin A
Herbimycin A is an ansamycin antibiotic that acts as a Src family kinase inhibitor that binds to the SH domain and inhibits the activity of p60v-src and p210BCR-ABL. Learn MoreStarting at: $125.00
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N,N-Dimethylsphingosine
N,N-Dimethylsphingosine is a competitive sphingosine kinase (SphK) inhibitor which exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells, and inhibits sphingosine phosphorylation. Learn MoreStarting at: $90.00
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SK1-I
SK1-I is a sphingosine kinase (SphK) inhibitor which inhibits the growth of both U937 and Jurkat T cells, and suppresses proliferation and induces apoptosis in several human glioblastoma cell lines. Learn MoreStarting at: $180.00
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SKI II
SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Learn MoreStarting at: $99.00
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BRD 7389
BRD 7389 is a p90 ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively), which upregulates insulin expression in terminally differentiated pancreatic α-cells. Learn MoreStarting at: $139.00
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SB 590885
SB 590885 is a potent B-Raf inhibitor (Kd = 0.3 nM), which is elective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively), and decreases anchorage-independent growth of melanoma cell lines. It also inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. Learn MoreStarting at: $159.00
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Rp-8-Br-PET-cGMPS
Rp-8-Br-PET-cGMPS is a competitive, reversible cGMP-dependent protein kinase (PKG) inhibitor; cGMP analog. Learn MoreStarting at: $135.00
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KT 5823
KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively), which inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM. Learn MoreStarting at: $115.00
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RuBi-Dopa
RuBi-Dopa is a RuBi-caged dopamine; exhibits two-photon sensitivity, and enables non-invasive, optical activation of dopamine receptors with the spatial resolution of a single dendritic spine. Learn MoreStarting at: $199.00
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KT 5720
KT 5720 is a potent, selective inhibitor of protein kinase A (Ki = 60 nM). Learn MoreStarting at: $165.00
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Cyclapolin 9
Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor (IC50 = 500 nM). Learn MoreStarting at: $105.00
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ML 9 hydrochloride
ML 9 hydrochloride is a selective inhibitor of myosin light chain kinase (MLCK). Ki values are 32, 4, and 54 μM for PKA, MLCK, and PKC respectively, which inhibits STIM1-plasma membrane interactions, and preventing store-operated Ca2+ entry (SOCE). Learn MoreStarting at: $90.00
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2-Deoxy-D-glucose
2-Deoxy-D-glucose is a non-metabolizable glucose analog which inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Learn MoreStarting at: $80.00
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CZC 54252 hydrochloride
CZC 54252 hydrochloride is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC50 values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). Learn MoreStarting at: $145.00
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Amlexanox
Amlexanox is a selective inhibitor of TANK-binding kinase 1 (TBK1) and IKKε. Learn MoreStarting at: $63.00
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ACHP
ACHP is a IκB kinase inhibitor (IC50 values are 8.5 and 250 nM for IKKβ and IKKα respectively), which inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis. Learn MoreStarting at: $209.00
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PF 184
PF 184 is a Potent and selective IKKβ inhibitor (IC50 = 37 nM), which displays selectivity over 85 other kinases and inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress. Learn MoreStarting at: $195.00
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IKK 16
IKK 16 is a selective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively), which inhibits TNF-α-stimulated IκB degradation and LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis. Learn MoreStarting at: $125.00
