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Signal Transduction
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NDT 9513727
NDT 9513727 is a potent C5a receptor (C5aR) competitive antagonist (IC50 = 11.6 nM); selective for human C5aR (IC50 values for rat and mouse C5aR are > 10 μM), which exhibits inverse agonist pharmacokinetics. Learn MoreStarting at: $189.00
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Leptomycin B
Leptomycin B, an antifungal antibiotic, is an inhibitor of the nuclear export of proteins that inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Learn MoreStarting at: $239.00
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Exo1
Exo1 is a reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Learn MoreStarting at: $95.00
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Eeyarestatin I
Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD), which specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Learn MoreStarting at: $149.00
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MG 132
MG 132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM) which inhibits TNF-α-induced NF-κB activation and IκBα degradation. Learn MoreStarting at: $75.00
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AM 114
AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome that inhibits cell growth in human colon cancer HCT116 p53+/+ cells. Learn MoreStarting at: $99.00
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SANT-2
SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM), which displays allosteric binding characteristics similar to SANT-1. Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively). Learn MoreStarting at: $139.00
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HPI 1
HPI 1, a Hedgehog (Hh) signaling inhibitor, inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells with IC50 values of 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation. Learn MoreStarting at: $129.00
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20(S)-Hydroxycholesterol
20(S)-Hydroxycholesterol is a allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein that activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). Learn More -
Jervine
Jervine is an inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM), which binds directly to Smoothened (Smo), and inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Learn MoreStarting at: $159.00
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AY 9944 dihydrochloride
AY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms, which inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. Learn MoreStarting at: $119.00
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U 18666A
U 18666A is an inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Learn MoreStarting at: $139.00
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Ciliobrevin A
Ciliobrevin A is a hedgehog (Hh) pathway antagonist which blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Learn MoreStarting at: $119.00
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SR 11302
SB 205384 is a GABAA receptor modulator; slows current decay. Learn MoreStarting at: $110.00
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Carbenoxolone disodium
Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. Learn MoreStarting at: $65.00
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SD 1008
SD 1008 is a JAK2/STAT3 signaling pathway inhibitor, which inhibits activation of STAT3, JAK2 and Src. Learn MoreStarting at: $109.00
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MDL 28170
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B that rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Learn MoreStarting at: $65.00
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Calpeptin
Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Learn MoreStarting at: $90.00
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Gallein
Gallein is an inhibitor of G protein βγ subunit-dependent signaling, which blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells. Learn MoreStarting at: $55.00
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Gue 1654
Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator, which selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Learn MoreStarting at: $90.00
