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5-HT Receptors
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PNU 109291
PNU 109291 is a potent and selective 5-HT1D receptor agonist that displays > 600-fold selectivity over 5-HT1A and 5-HT2A receptors and no activity at 5-HT1B, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. Learn MoreStarting at: $155.00
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GR 46611
GR 46611 is a 5-HT1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT1D receptor ligands. Learn MoreStarting at: $120.00
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BIMU 8
BIMU 8 is a potent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors), which binds to receptors in a mechanism different to that of the endogenous ligand 5-HT. Learn MoreStarting at: $125.00
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SB 203186 hydrochloride
SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors. Learn MoreStarting at: $95.00
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GR 113808
GR 113808 is a potent, selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, and Kd = 0.15 nM for binding to cloned human 5-HT4 receptors) which displays > 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. Learn MoreStarting at: $115.00
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GR 125487 sulfamate
GR 125487 sulfamate is a potent and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for porcine 5-HT4). Learn MoreStarting at: $135.00
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SB 204070
SB 204070 is a potent and selective 5-HT4 receptor antagonist (pIC50 = 10.1). Displays >5000-fold selectivity for 5-HT4 over 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2C, and 5-HT3 receptors which exhibits anxiolytic activity upon systemic administration in vivo. Learn MoreStarting at: $140.00
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ML 10302 hydrochloride
ML 10302 hydrochloride is a potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo. Learn MoreStarting at: $80.00
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RS 23597-190 hydrochloride
RS 23597-190 hydrochloride is a high affinity, selective competitive antagonist at 5-HT4 receptors. Learn MoreStarting at: $90.00
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Tegaserod maleate
Tegaserod maleate is a partial agonist of 5-HT4 (Ki = 12 nM). Learn MoreStarting at: $119.00
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RS 39604 hydrochloride
Potent cholinesterase inhibitor, a cognition enhancer in vivo. Learn MoreStarting at: $110.00
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RS 67333 hydrochloride
RS 67506 hydrochloride is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Learn MoreStarting at: $95.00
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RS 67506 hydrochloride
(2R,4R)-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Learn MoreStarting at: $90.00
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CJ 033466
CJ 033466 is a potent and selective 5-HT4 partial agonist (EC50= 0.927 nM) with > 1000-fold selectivity for 5-HT4 over other 5-HT and D2 receptors. Learn MoreStarting at: $119.00
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EMD 281014 hydrochloride
EMD 281014 hydrochloride is a selective 5-HT2A antagonist; displays high affinity for human 5-HT2A over 5-HT2C receptors (Ki values are 0.87 and 557 nM respectively). Learn MoreStarting at: $115.00
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Ipsapirone
Ipsapirone is a selective 5-HT1A receptor agonist with a Ki value of 10 nM. Learn MoreStarting at: $99.00
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Cyanopindolol hemifumarate
Cyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist. Learn MoreStarting at: $99.00
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Zotepine
Zotepine is a 5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Learn MoreStarting at: $65.00
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AT 1015
AT 1015 is a long-acting 5-HT2A receptor antagonist which inhibits vasoconstriction and blocks platelet aggregation. Learn MoreStarting at: $115.00
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(S)-WAY 100135 dihydrochloride
(S)-WAY 100135 dihydrochloride is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). Learn MoreStarting at: $110.00
