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5-HT2A Receptors
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MDL 11,939
MDL 11,939 is an Orally active 5-HT2A receptor antagonist, which displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively). Learn MoreStarting at: $105.00
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Nefazodone hydrochloride
Nefazodone hydrochloride is a serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Learn MoreStarting at: $89.00
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Spiperone hydrochloride
Spiperone hydrochloride is a 5-HT2A serotonin and selective D2-like dopamine receptor antagonist. Learn MoreStarting at: $99.00
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Mesulergine hydrochloride
Mesulergine hydrochloride is a 5-HT2A and 2C receptor antagonist and D2-like dopamine receptor partial agonist with antiprolactin and antiparkinsonian effects in vivo. Learn MoreStarting at: $129.00
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R-96544 hydrochloride
PPARγ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ. Acts as a PPARγ agonist in an ECV304 cell line. Learn MoreStarting at: $120.00
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Melperone hydrochloride
CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4), which competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast). Learn MoreStarting at: $65.00
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EMD 281014 hydrochloride
EMD 281014 hydrochloride is a selective 5-HT2A antagonist; displays high affinity for human 5-HT2A over 5-HT2C receptors (Ki values are 0.87 and 557 nM respectively). Learn MoreStarting at: $115.00
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DOI hydrochloride
Brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively), which reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Learn MoreStarting at: $90.00
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Zotepine
Zotepine is a 5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Learn MoreStarting at: $65.00
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AT 1015
AT 1015 is a long-acting 5-HT2A receptor antagonist which inhibits vasoconstriction and blocks platelet aggregation. Learn MoreStarting at: $115.00
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4F 4PP oxalate
4F 4PP oxalate is a selective 5-HT2A antagonist with almost as high affinity (Ki = 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki = 620 nM). Learn MoreStarting at: $98.00
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Sarpogrelate hydrochloride
Sarpogrelate hydrochloride is a selective 5-HT2A receptor antagonist (pKi values are 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively), which displays selectivity over 5-HT1, 5-HT3, 5-HT4 H1, H2, M3, α1-adrenergic, α2-adrenergic and β-adrenergic receptors. Learn MoreStarting at: $100.00
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DV 7028 hydrochloride
DV 7028 hydrochloride is a selective 5-HT2A receptor antagonist (Ki = 22 nM for at 5-HT2 receptors). Learn MoreStarting at: $105.00
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Fananserin
Fananserin is a 5-HT2A receptor antagonist that also displays high affinity at D4 receptors (Ki values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT2A, D4, H1, α1, 5-HT1A and D2 receptors respectively). Learn MoreStarting at: $95.00
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Altanserin hydrochloride
Altanserin hydrochloride is a potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A, α1, 5-HT2C, D2 and 5-HT1A respectively). Learn MoreStarting at: $95.00
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TCB-2
TCB-2 is a high affinity 5-HT2A receptor agonist that potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors with an EC50 value of 36 nM. Learn MoreStarting at: $139.00
